摘要
目的 考察小剂量、个体化、联合用药的降压方案对老年高血压患者的临床疗效和安全性.方法 回顾性分析2012 年5 月至2013 年10 月来我院就诊、并随访至少半年的68 例老年高血压患者的临床资料.其中男33 例,女35 例;年龄60～81 岁,平均（69.5±8.6）岁.患者均接受原发基础疾病的治疗和并发症的治疗以及降血压药物治疗.据此将患者分为传统药物组（13 例）、单药组（27 例）和联合用药组（28 例）.考察患者接受不同降压用药方案的临床疗效和安全性.结果 三组均存在依从性不好、患者中断用药的情况,但三组的具体原因各异,其中联合用药组出现依从性不好的例次最低;控制血压方面,治疗后三组的降压效果（收缩压）差异有统计学意义（P〈0.05）;临床疗效方面,联合用药组的总有效率更高,差异具有统计学意义（P〈0.05）.随访半年,三组均未出现严重不良事件.结论 传统药物的临床降压效果不尽如人意,且因药物临床疗效不佳或不良反应多等原因故而患者的依从性较差;单药降压治疗不及联合用药的总有效率高;针对老年高血压有并发症的患者,临床需采用小剂量、个体化的联合用药方案进行降压治疗来获得满意的临床疗效和可靠的安全性.
ObjectiveTo investigate the clinical efficacy and safety of low dose, individualized, and combined medication on the elderly patients with hypertension.Methods The research object was the clinical data of 68 elderly patients with hypertension in our hospital from May 2012 to October 2013, all patients were followed up for at least six months. Among them, 33 cases were male and 35 were female, their age was 60-81 years old, and the average age was (69.5±8.6) years. Patients were treated with the treatment for the basic diseases and the combined disease, as well as lowering blood pressure medication. The patients were divided into 3 groups: traditional medicine group (13 cases), single drug group (27 cases) and combined treatment group (28 cases). To investigate the clinical efficacy and safety of patients after receiving different antihypertensive treatment regimens.Results In the three groups, there were all poor compliance, but the specific reasons in the three groups was different. Among them, the combined treatment group had better compliance than the other two groups (P<0.05). In the effect on controlling blood systolic pressure after treatment, it was significantly different in the three groups (P<0.05). The clinical efficacy in the combined treatment group was more higher (P<0.05). Followed up for six months, there was no serious adverse events in all the patients of the three groups.Conclusions The clinical efficacy of traditional medicine is unsatisfactory, and the total effective rate is more higher in combined treatment group for high blood systolic pressure. The clinical efficacy and safety of low dose and combination therapy should be used in the treatment of elderly patients with high blood pressure.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第24期60-62,共3页
Chinese Journal of Clinicians(Electronic Edition)
关键词
高血压
小剂量
个体化
联合用药
Hypertension
Low dose
Individual
Combination therapy
