摘要
目的考察参芪多糖泡腾片对小鼠和大鼠的免疫调节作用。方法通过碳粒廓清试验及2,4-二硝基氟苯(DNFB)诱导小鼠迟发型变态反应,通过测定小鼠右耳肿胀度和肝、脾、胸腺指数,考察参芪多糖泡腾片对小鼠的免疫调节作用;通过测定注射用环磷酰胺(CTX)致免疫低下大鼠脾指数、胸腺指数,肿瘤坏死因子-α(TNF-α)和白介素-2(IL-2)水平等的变化,考察参芪多糖泡腾片对大鼠的免疫调节作用。结果参芪多糖泡腾片能够升高小鼠肝指数、脾指数、廓清指数K值及吞噬指数α值;增强DNFB诱导的小鼠迟发型变态反应;并升高CTX所致免疫低下大鼠脾指数和TNF-α、IL-2水平。结论参芪多糖泡腾片具有增强小鼠特异性免疫和非特异性免疫功能、提高大鼠免疫力的作用。
Objective To investigate the immunoregulation effects of Shenqi Polysaccharide Effervescent Tablets in mice and rats. Methods The carbon particle clearance test and 2,4-dinitrofluorobenzene（DNFB） were used to induce the mice delayed type hypersensitivity reaction,the changes of the spleen index,thymus index,TNF-α and IL-2 in immunosuppressed rats caused by cyclophosphamide（CTX） were detected for investigating the immunoregulation effects of Shenqi Polysaccharide Effer-vescent Tablets in rats. Results Shenqi Polysaccharide Effervescent Tablets could increase the liver index,spleen index,clearance index K value and phagocytic index α value;and enhanced the spleen index,TNF-α and IL-2 levels in immunosuppressed rats caused by CTX. Conclusion Shenqi Polysaccharide Effervescent Tablets can enhance specific immune and non-specific immune function of mice and increases the immunity in rats.
出处
《现代医药卫生》
2016年第1期51-53,共3页
Journal of Modern Medicine & Health
关键词
多糖类
片剂
党参/药理学
黄芪/药理学
免疫活性
超敏反应
迟发型
碳粒廓清试验
Polysaccharides
Tablets
Codonopsis pilosula/pharmacology
Astragalus membranaceus/pharmacology
Immunocompetence
Hypersensitivity
Delayed
Carbon clearance test
