摘要
[目的]研究李亚平教授治疗失眠的用药规律。[方法]筛选出李亚平教授2013至2015年门诊治疗的失眠病例及相关的200首中药处方,基于中医传承辅助系统(V2.5),录入并核对处方,通过该系统中'数据分析模块'的方剂分析功能,对所选数据进行用药规律挖掘,分析药物频次、组合频次、关联规则、核心组合及新组方。[结果]李亚平教授治疗失眠的常用药物包括首乌藤、郁金、珍珠母、合欢皮、茯苓、五味子、酸枣仁、醋延胡索、徐长卿、当归、制远志肉、麦冬等。在常用药物中挖掘出3~4味药物核心组合20个,并于此基础上,挖掘出10个新处方。新处方皆组方精当,理法兼备,体现了李师辨治失眠'病证结合'的思想,从多个角度论治失眠,如'旱莲草、地骨皮、醋延胡索、徐长卿、生地黄、女贞子'为养阴清热安神方,其余诸方也各自适用于不同证型的失眠。[结论]李亚平教授治疗失眠经验丰富,理法兼备,多用益气养心、安神定志之品,为治疗不同证型的失眠提供了更广泛的思路。中医传承辅助系统对挖掘名中医临床经验具有重要实用价值。
[Objective]To explore the medication rules of Professor LI Yaping in treating insomnia.[Methods]Insomnia cases during 2013 to 2015 treated by Professor LI were selected,and 200 prescriptions were obtained.Based on the traditional Chinese medicine inheritance support system(V2.5),the prescriptions were input and checked.Through the function of prescription analysis in'data analysis system',medication rules mining was carried out from the selected data to analyze frequency of Chinese herbs,combination frequency,association rules,core combination and new prescription.[Results]Professor LI Yaping’s commonly used medicines for insomnia include Caulis Polygoni Multiflori,Curcumae Radix,Nacre Concha,Albiziae cortex,Poria cocos,Schisandrae Chinensis Fructus,Ziziphi Spinosae Semen,Rhizoma Corydalis processed with vinegar,Radix Cynanchi Paniculati,Angelica Sinensis,Processed Polygala tenuifolia,Ophiopogon japonicas,etc.Twenty core combinations of 3 to 4 herbs were excavated from commonly used medicines.On this basis,ten new prescriptions were excavated to provide a broader idea for the treatment of insomnia with different syndromes.The new prescriptions are well-formulated,contain principle and method of traditional Chinese medicine,and they fully embody Professor LI’s thoughts of'combining disease with syndrome',treat insomnia from different perspectives.For example,'Eclipta,Lycii Cortex,Rhizoma Corydalis processed with vinegar,Radix Cynanchi Paniculati,dry Rehmannia root,Fructus Ligustri Lucidi'is a prescription for nourishing Yin,clearing away heat and tranquilizing.The other prescriptions were also suitable for insomnia of different syndromes.[Conclusion]Professor LI Yaping is well experienced in treating insomnia by invigorating Qi and nourishing heart,tranquilizing and sedating the mind,her experience provided a broader idea for the treatment of insomnia of different syndromes.The traditional Chinese medicine inheritance support system is useful in analyzing clinical experience of famous TCM physicians.
作者
姜洋
俞梦楠
马彩艳
陈嘉斌
郑菊萍
刘兰英
李亚平
JIANG Yang;YU Mengnan;MA Caiyan(Tongde Hospital of Zhejiang Province,Hangzhou 310012,China;The Second Clinical Medical College of ZhejiangChinese Medical University)
出处
《浙江中医药大学学报》
CAS
2019年第9期987-992,共6页
Journal of Zhejiang Chinese Medical University
基金
国家自然科学基金项目(81403502)~~
关键词
失眠
关联规则
熵聚类
用药规律
中药
数据挖掘
insomnia
association rules
entropy clustering
medication rules
traditional Chinese medicine
data mining
