摘要
目的探讨接受根治性放疗的局部晚期非小细胞肺癌患者发生医院感染病原菌分布及危险因素分析,为降低医院感染率提供依据。方法回顾性分析2012年5月-2014年6月70例局部晚期非小细胞肺癌患者的临床资料,分析其感染病原菌分布及相关危险因素;采用SPSS19.0软件进行统计分析。结果 70例局部晚期非小细胞肺癌患者发生医院感染31例,感染率为44.29%,感染部位以呼吸道、胃肠道、泌尿系统为主,分别占45.16%、19.36%、16.13%;共检出病原菌40株,其中革兰阴性菌、革兰阳性菌、真菌分别占52.50%、42.50%、5.00%;革兰阴性菌以大肠埃希菌、铜绿假单胞菌为主,分别占20.00%、15.00%;革兰阳性菌则以金黄色葡萄球菌、表皮葡萄球菌为主,分别占15.00%、12.50%;单因素分析表明,年龄、住院时间、血红蛋白含量、白蛋白含量、合并其他疾病是局部晚期非小细胞肺癌患者发生医院感染的危险因素(P<0.05),logistic回归分析发现,年龄、住院时间、血红蛋白含量、白蛋白含量、合并其他疾病等是发生医院感染的独立危险因素(P<0.05)。结论局部晚期非小细胞肺癌患者发生医院感染相关危险因素较多,应采取相应措施,加强感染管理及积极治疗患者基础疾病,以降低医院感染率。
OBJECTIVE To explore the distribution of pathogens causing nosocomial infections in the patients with locally advanced non-small cell lung cancer undergoing radical radiotherapy and analyze the risk factors so as to reduce the incidence of the nosocomial infections.METHODS The clinical data of 70 patients with locally advanced non-small cell lung cancer who were treated in the hospital from May 2012 to Jun 2014 were retrospectively analyzed,the distribution of the pathogens causing the infections was observed,the related risk factors for the infections were observed,and the statistical analysis was performed with the use of SPSS19.0software.RESULTS Of70 patients with locally advanced non-small cell lung cancer,31 had the nosocomial infections with the infection rate of 44.29%,of whom 45.16% had respiratory tract infections,19.36% had gastrointestinal tract infections,and 16.13% had urinary system infections.A total of 40 strains of pathogens were isolated,of which 52.50%were gram-negative bacteria,42.50% were gram-positive bacteria,and 5.00% were fungi;the Escherichia coli and Pseudomonas aeruginosa were the predominant species of the gram-negative bacteria,accounting for 20.00%and 15.00%,respectively;the Staphylococcus aureus and Staphylococcus epidermidis were dominant among the gram-positive bacteria,accounting for 15.00% and 12.50%,respectively.The univariate analysis indicated that the risk factors for the nosocomial infections in the patients with locally advanced non-small cell lung cancer included the age,length of hospital stay,content of hemoglobin,content of albumin,and complication of other diseases（P〈0.05）.The logistic regression analysis showed that the independent risk factors for the nosocomial infections included the age,length of hospital stay,content of hemoglobin,content of albumin,and complication of other diseases（P〈0.05）.CONCLUSIONThere are a variety of risk factors associated with the nosocomial infections in the patients with locally advanced non-small cell lung cancer.It is necessary to take targeted prevention measures,strengthen the control of the infections,and conduct the active treatment of the patients with underlying diseases so as to reduce the incidence of the nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第1期95-97,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(30800347)
关键词
局部晚期非小细胞肺癌
根治性放疗
感染
危险因素
Locally advanced non-small cell lung cancer
Radical radiotherapy
Infection
Risk factor
