摘要
目的探讨干扰素栓剂治疗宫颈人乳头状瘤病毒(HPV)感染的临床价值,为临床选择术式提供参考。方法选择2013年1月-2014年1月80例宫颈病变实施宫颈电热圈环切术(LEEP)手术患者,所有患者术前检测均有高危HPV感染,按照患者自愿原则分为对照组与观察组,各40例,观察组在手术治疗的基础上联合使用干扰素栓剂治疗,对比两组患者治疗有效率、HPV转阴率、症状评分等指标。结果观察组治疗有效率为95.00%,明显高于对照组80.00%,对比差异有统计学意义(χ2=4.114,P<0.05);观察组转阴率为85.00%,明显高于对照组65.00%,对比差异均有统计学意义(χ2=4.267,P<0.05);观察组治疗后临床症状体征积分、中医证候评分分别为3.57±0.57、3.42±0.94,改善均优于对照组,对比差异有统计学意义(P<0.05);观察组平均创面愈合时间为(4.51±1.01)周,明显短于对照组,对比差异有统计学意义(t=5.847,P<0.05)。结论干扰素栓剂治疗宫颈人乳头状瘤病毒感染临床效果好,利于改善临床症状,值得临床推广应用。
OBJECTIVE To explore the clinical value of interferon suppository in treatment of cervical human papillomavirus infection（HPV）so as to provide guidance for selection of surgery mode.METHODS A total of 80 patients with cervical lesions who underwent the cervical loop electrosurgical excision procedure（LEEP）in the hospital from Jan 2013 to Jan 2014 were enrolled in the study,and all the enrolled patients were detected to have the high-risk HPV infections before the surgery.The patients were divided into the control group and the observation group according to the principle of voluntary,with 40 cases in each.The observation group was treated with surgical procedure combined with interferon suppository.The effective rate of treatment,negative rate of HPV,and symptom score were observed and compared between the two groups of patients.RESULTS The effective rate of treatment of the observation group was 95.00%,significantly higher than 80.00% of the control group（χ2=4.114,P〈0.05）.The negative rate of the observation group was 85.00%,significantly higher than 65.00% of the control group（χ2=4.267,P〈0.05）.The clinical symptom score and TCM syndrome score of the observation group were respectively 3.57±0.57 and 3.42±0.94 after the treatment,significantly better than those of the control group（P〈0.05）.The average wound healing time of the observation group was（4.51±1.01）weeks,significantly shorter than that of the control group（t=5.847,P〈0.05）.CONCLUSIONThe interferon suppository can achieve significant clinical effect on treatment of the cervical human papillomavirus infection and is conducive to the improvement of clinical symptoms,and it is worthy to be promoted in the hospital.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第1期164-166,共3页
Chinese Journal of Nosocomiology
基金
浙江省卫生厅基金资助项目项目(2013KYB213)
关键词
干扰素
人乳头状瘤病毒
感染
宫颈电热圈环切术
Interferon
Human papillomavirus
Infection
Cervical loop electrosurgical excision procedure
