摘要
目的:探索幽门螺杆菌(Hp)的分型以及Hp分型在消化性溃疡中的构成比,评价Hp分型对消化性溃疡的临床意义。方法:采用免疫印迹法检测89例确诊消化性溃疡(胃镜确诊)且伴有Hp感染患者血清中与Hp感染相关的抗体。根据检测到的细胞毒素(Cag A)、空泡毒素(Vac A)、尿素酶(Urease)等其他Hp抗体,将患者分为Ⅰ型或Ⅱ型Hp感染。结果:在89例消化性溃疡患者中Ⅰ型感染胃溃疡和十二指肠溃疡发生率显著高于Ⅱ型感染,差异具有统计学意义(P<0.05)。而69例HpⅠ型感染者中,Cag A+Vac A双阳性率显著高于单个Cag A/Vac A抗体检出率,差异具有统计学意义(P<0.05)。结论:用免疫印迹法对消化性溃疡进行分型,有利于病情的判断,对治疗有一定的指导作用。
Objective： To explore the composition ratio of pylori Helicobacter（Hp） and Hp typing in peptic ulcer,and to evaluate the clinical significance of Hp typing for peptic ulcer. Methods：Detection of antibody which associated with Hp infection in serum of 89 cases patients of peptic ulcer confirmed（gastroscope diagnosis） and Hp infection.According to the detected cell toxin（Cag A）, vacuolating cytotoxin（Vac A）, urease（above） and other Hp antibody, the patients were classified as type I or type Ⅱ Hp infection. Results： the incidence of type I infection gastric ulcer and duodenal ulcer in 89 patients was significantly higher than that of type Ⅱ infection, which had statistical significance（P0.05）. In 69 patients with Hp I infection, the positive rate of Cag A＋Vac A was significantly higher than that of a single Cag A/Vac A antibody, which was statistically significant（P0.05）. Conclusion：Using western blot method to classification of peptic ulcer is advantageous to the condition judgment, and it also has a certain guiding role to treatment.
出处
《安徽卫生职业技术学院学报》
2015年第6期70-71,73,共3页
Journal of Anhui Health Vocational & Technical College
