摘要
目的:研究学龄期非酒精性脂肪性肝病(NAFLD)患儿中代谢综合征(MS)的发病情况,探讨学龄儿童NAFLD与MS的关系。方法:选取在我院就诊的NAFLD患儿41例作为NAFLD组,同期住院的60例单纯性肥胖患儿作为对照组,检测患儿体质量、身高、血压、腹围、血生化、空腹血糖,进行肝脏彩色多普勒超声检查,分析两组患儿代谢综合征发生率及生化改变。结果:NAFLD组和对照组比较,除甘油三脂(TG)外NAFLD组丙氨酸氨基酸转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、ALT/AST及总胆固醇(TC)均较对照组升高,而NAFLD组高密度酯蛋白胆固醇(HDL-C)低于对照组;NAFLD组MS发生率为41.46%,高于对照组的21.67%,两组比较差异有统计学意义(χ2=4.57,P=0.03)。结论:肥胖儿童若合并NAFLD,则其发生MS的风险明显增加。NAFLD早期应当积极地改变生活方式、减轻体质量、调节血脂、控制血糖,使肝脏损害早期逆转,防止或减缓其进一步发展。
Objective： To investigate the relationship between non-alcoholic fatty liver disease（ NAFLD） and metabolic syndrome（ MS） in obese school children. Methods： Forty-one children with NAFLD were studied,and 60 children with simple obesity as control group. Body weight,height,blood pressure,abdominal circumference,blood biochemistry,fasting plasma glucose and ultrasound scanning of liver were measured,and incidence of metabolic syndrome and biochemical change were analyzed. Results： Compared with the control group,NAFLD group showed a higher degree of alanine aminotransferase（ ALT）,aspartate amino transferase（ AST）,total cholesterol（ TC）,but a lower degree of high density lipoprotein cholesterol（ HDL）. The incidence of MS was more common in NAFLD group（ 41.46%） than that in the control group（ 21.67%）. Conclusion： There is a high prevalence of MS in NAFLD individuals among overweight or obesity children. NAFLD children should change lifestyle,reduce body mass,regulate blood lipids and control diabetes,in order to reverse the liver damage earlier,and prevent further development.
出处
《儿科药学杂志》
CAS
2016年第1期20-22,共3页
Journal of Pediatric Pharmacy
关键词
非酒精性脂肪性肝病
代谢综合征
肥胖
儿童
non-alcoholic fatty liver disease
metabolic syndrome
obesity
children
