摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea-hypopnea syndromes,OSAHS)患者血清炎性因子白细胞介素-6(Interleukin,IL-6)、白细胞介素-17(Interleukin,IL-17)水平变化及临床意义。方法:回顾性分析2013年5月-2014年10月间本院呼吸科门诊及住院部经多导睡眠图(Polysomnagraphy,PSG)监测确诊的102例OSAHS患者,及同期本院体检中心98例健康体检者的一般临床资料、睡眠呼吸暂停低通气指数(Apnea-hypopnea index,AHI)、最低血氧饱和度(Lowest arterial oxygen saturation,LSaO_2)。采集静脉血,分离血清,酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)检测患者血清IL-6、IL-17水平并分析其与OSAHS的相关性。结果:与健康对照组比较,OSAHS组的血清IL-6、IL-17水平均升高,差异有统计学意义(P<0.05),且血清IL-6、IL-17水平随OSAHS分布严重程度的升高而升高。OSAHS组的血清IL-6、IL-17水平与AHI呈正相关(r=0.868,P<0.05;r=0.896,P<0.05),而与LSaO_2呈负相关(r=-0.769,P<0.05;r=-0.703,P<0.05)。结论:血清炎性因子IL-6、IL-17水平在OSAHS组患者中升高,提示其参与OSAHS疾病进程,可以作为OSAHS严重程度的生物学指标。
Objective：To discuss the change and clinical significance of serum IL-6 and IL-17 levels in patients with obstructive sleep apnea-hypopnea syndromes（OSAHS）.Method：102 patients with OSAHS who were diagnosed by polysomnagraphy（PSG） and 98 cases of healthy as control group were selected from May 2013 to Octomber 2014,the general clinical data, apnea-hypopnea index（AHI） and lowest arterial oxygen saturation（LSaO2） of them were retrospectively analyzed.The serum IL-6 and IL-17 levels were determined by enzyme-linked immunosorbent assay（ELISA）, and its correlation with OSAHS were analyzed. Result： Compared with the control group,the serum IL-6 and IL-17 levels of OSAHS patients increased and increased with the severity of OSAHS,there was statistically significant difference between them（P〈0.05）.The serum IL-6 and IL-17 levels of OSAHS patients presented positively correlated with AHI（r=0.868,P〈0.05;r=0.896,P〈0.05）,but negatively correlated with LSaO2（r=-0.769,P〈0.05;r=-0.703,P〈0.05）.Conclusion：The levels of serum inflammatory cytokines IL-6 and IL-17 are higher in OSAHS group,suggests its participation in OSAHS disease process,and it can be used as biological index of the severity of OSAHS.
出处
《中国医学创新》
CAS
2015年第32期5-7,共3页
Medical Innovation of China
基金
内蒙古自治区自然科学基金项目(2011MS1179)
