摘要
低氧性肺动脉是一类严重影响人类健康的高致死性疾病,其主要的结构和功能异性表现为肺血管紧张性的持续性增高和血管构型的改变。进行性增高的肺血管压力最终将导致右心室负荷的加重和心力衰竭。由于发病机制复杂,因此尽管西地那非和波生坦等靶向药物可以部分缓解肺动脉高压的临床症状,然而长期疗效仍旧不佳。近年来,大量研究表明,免疫炎症反应在低氧性肺动脉高压的发生过程中起到了重要作用。在此,笔者对其作一综述。
Hypoxic pulmonary hypertension（HPH） is a highly lethal disease seriously affect human health.The major structural and functional specificity are the persistent increase in the pulmonary vascular tone and the changes of the vascular structure.Progressive pulmonary vascular pressure will eventually lead to increased right ventricular load and heart failure.Because the mechanism of PH is complexity,even though the clinical symptoms of HPH can be relieved partly by targeted medicine such as Sildenafil and Bosentan,but the long-term effect is still not good.In resent years,much more studies indicated that immuno-inflammation play a pivotal role in the mechanism of HPH.So,here we make a review about these in the present article.
出处
《中国医学创新》
CAS
2015年第32期150-153,共4页
Medical Innovation of China
基金
河北省医学科学研究重点课题计划项目(20130594)
关键词
低氧
肺性
高血压
免疫
炎症
Hypoxia
Pulmonary
Hypertension
Immune
Inflammation
