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环氧化酶2抑制剂抗卵巢癌作用的研究进展 被引量：8

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摘要 卵巢癌是妇科常见的恶性肿瘤之一,由于起病隐匿。现有的化疗方案常由于化疗药物不敏感、耐药等原因导致肿瘤易复发,化疗毒副反应大而使卵巢癌的死亡率一直居高不下,因而寻找一种安全、有效的化疗方案一直是妇科肿瘤工作者面临的难题。Cox-2的表达水平与卵巢癌分型、分化程度、转移密切相关,直接影响卵巢癌患者的预后,对判断卵巢肿瘤的恶性度有一定的提示作用,是卵巢癌治疗中的一个潜在的靶点。Cox-2抑制剂可通过PI3K/Akt、NF-κB、Fas L、RAS/RAF/MAPK/ERK等多种途径促进肿瘤细胞凋亡,抑制细胞增殖,抑制血管生成,从而发挥抗肿瘤作用。Cox-2抑制剂还可与化疗药物协同作用,提高化疗药物的敏感性、减少耐药,增强化疗效果。本文就cox-2抑制剂在卵巢癌治疗中的研究现状作以总结。
作者 邓琳 冯定庆 凌斌
机构地区 中日友好医院妇产科
出处 《现代妇产科进展》 CSCD 北大核心 2015年第11期876-878,共3页 Progress in Obstetrics and Gynecology
基金 国家自然科学基金项目(No:81372777 81372779)
关键词 卵巢癌 COX-2 紫杉醇 铂类
分类号 R711.75 [医药卫生—妇产科学]
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  • 1Moran EM.Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks[J].J Environ Pathol Toxicol Oncol,2002,21:193-220.
  • 2Prescott S M,Fitzpatrick F A.Cyclooxcygen-2 and carcinogenesis[J].Biochem Biophys Acta,2000,1470(2):69-78.
  • 3Garcia-Rodrigue LA,Huerta A lvare C,et al.Reduced risk of colorectal cancer among long-term users of aspirin and nonsteroidal anti-inflammatory drugs[J].Epidemidogy,2001,12(1)88-93.
  • 4Dore M,Cote LC,Mitchell A,et al.Expression of prostaglandin G/H synthase type 1,but not type 2,in human ovarian adenocarcinomas[J].J Histochem Cytochem,1998,46:77-84.
  • 5Matsumoto Y,Ishiko O,Deguchi M,et al.Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms[J].Int J Mol Med,2001,8:31-36.
  • 6Klimp AH,Hollema H,Kempinga C,et al.Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages[J].Cancer Res,2001,61:7 305-7 309.
  • 7Sang Soo Seo,Yong Sang Song,Dae-hee Kang,et al.Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer[J].Gynecologic oncology,2004,92:927-935.
  • 8Zhang GS,Tu CQ,Zhang GY,et al.Indomethacin induces apoptosis and inhibits proliferation in chronic myeloid leukemia cells[J].Leukemia Res,2000,24:385-392.
  • 9Hida T,Kozaki K,Muramatsu H,et al.Cyclooxygenase2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines[J].Clin Cancer Res,2000,6(5):2 006-2011.
  • 10Li HL,Zhang HW,Chen DD,et al.JTE-522,a selective COX-2 inhibitor,inhibits cell proliferation and induces apoptosis in RL95-2 cells[J].Acta Pharmacol Sin,2002,23(7):631-637.

共引文献22

同被引文献91

  • 1闫冰冰,李力.DNA甲基化与卵巢癌多药耐药及预后的关系[J].中国肿瘤生物治疗杂志,2015,22(3):281-289. 被引量：7
  • 2皮治兵,蒋宗滨.COX-2抑制剂临床研究新进展[J].中国疼痛医学杂志,2006,12(5):297-299. 被引量：5
  • 3Zeisberg M,Neilson E.Biomarkers for epithelial-mesenchymal transitions.[J].J Clin Invest,2009,119(6):1429-1437.
  • 4Yang J,Weinberg R.Epithelial-Mesenchymal transition:at the crossroads of development and tumor metastasis[J].Dev Cell,2008,14(6):818-829.
  • 5Bocca C,Ievolella M,Autelli R,et al.Expression of Cox-2in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.[J].Expert Opin Therapeutic Targets,2014,18(2):121-135.
  • 6Buys SS,Partridge E,Black A,et al.Effect of screening on ovarian cancer mortality:the Prostate,Lung,Colorectal and Ovarian(PLCO)Cancer Screening Randomized Controlled Trial[J].JAMA,2013,5(22):2295-2303.
  • 7Ferrandina G,Lauriola L,Zannoni GF,et al.Increased cyclooxygenase-2(COX-2)expression is associated with chemotherapy resistance and outcome in ovarian cancer patients[J].Ann Oncol,2002,13(8):1205-1211.
  • 8Giaginis C,Alexandrou P,Tsoukalas N,et al.Hu-antigen receptor(HuR)and cyclooxygenase-2(COX-2)expression in human non-small-cell lung carcinoma:associations with clinicopathological parameters,tumor proliferative capacity and patients'survival[J].Tumor Biol,2015,36(1):315-327.
  • 9Liu R,Zheng J,Li C,et al.Celecoxib induces epithelialmesenchymal transition in epithelial ovarian cancer cells via regulating ZEB1 expression[J].Arch Gynecol Obstet,2015,291:1361-1369.
  • 10Hu Z,Liu X,Tang Z,et al.Possible regulatory role of Snail in NF-κB-mediated changes in E-cadherin in gastric cancer[J].Oncol Rep,2013,29(3):993-1000.

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现代妇产科进展
2015年 第11期

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