摘要
目的：为了解综合医院中双环醇老年人群用药特征。方法：以全国18家大型三甲医院医院信息系统数据库中使用双环醇片的1 085例老年住院患者为研究对象,利用频数统计及关联规则分析其基本情况、合并疾病、合并用药。结果：患者年龄66~74岁居多,占75.48%;性别为男∶女≈2∶1;住院天数集中在15~28 d;合并西药以双环醇片＋营养补充药最常见;合并中药以双环醇片＋清热祛湿剂最常见;一种中药合并一种西药以甘草酸注射剂＋还原型谷胱甘肽为主;关联分析中以甘草酸注射剂＋呋塞米/胸腺肽/螺内酯最常见。结论：在中医药治疗肝病的临床中,医生应注意运用清热解毒祛湿、活血化淤、扶正固本的原则来辨证遣方和联合用药;双环醇片与甘草酸注射剂联合运用可能在治疗肝炎和预防肝癌方面产生一定的协同作用;双环醇与胸腺肽联合使用可能在治疗慢性乙型肝炎、预防老年人群肿瘤的发生和预防及治疗化疗药物所致肝损害方面均产生协同作用;双环醇片与甘草酸注射剂、还原型谷胱甘肽、螺内酯片、呋塞米、胸腺肽的多项联合用药可能在临床肝硬化腹水的治疗上产生积极的协同作用。
OBJECTIVE To learn about characteristics of bicyclol tablets used in elderly patients.METHODS A total of 1085 cases of hospital information system（HIS）data from18 Three-A hospitals were collected as research subjects to analyze their basic information,affiliated diseases,drug combinations by using frequency statistics method and association rules.RESULTS 75.48% of elderly patients were aged 66-74 years.Male and female ratio of patients was about 2∶1.The hospitalization duration was 15-28 days in more than one third inpatients.The most common western medicine combined with bicyclol tablets was dietary supplement.The most common traditional Chinese medicine combined with bicyclol tablets was heat and dampness clearing drug.When bicyclol tablets were combined with a traditional Chinese medicine and a western medicine,it was always combined with an injection and glutathione.The most common combination in association analysis was glycyrrhizic acid injection with other drugs,such as furosemide,thymosin and spironolactone.CONCLUSION In clinical practice to treat hepatic diseases by using traditional Chinese medicine,doctors should consider the prescription and combine different drugs by clearing heat and dampness,removing blood stasis and supporting healthy energy.Bicyclol tablets and glycyrrhizic acid injection may produce synergetic effects in treating hepatitis and preventing liver cancer.Bicyclol tablets and thymosin may produce synergetic effects when treating hepatitis B,preventing tumor and withstanding side effects of chemotherapeutic agents to liver.Bicyclol tablets may produce synergetic effects with glycyrrhizic acid injection,glutathione,spironolactone,furosemide and thymosin when treating cirrhotic with ascites.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2016年第1期32-37,共6页
Chinese Journal of Hospital Pharmacy
基金
中国中医科学院自主选题项目(PY1303)"中药上市后临床再评价关键技术创新团队"
中国中医科学院基本科研业务费自主选题项目(Z0291)"循证中医药证据核心科学问题深化研究"
关键词
双环醇
真实世界
医院信息系统
老年用药
合并用药
bicyclol tablets
real world database
hospital information system
elderly medication
drug combination
