摘要
目的观察黄芪颗粒对原发性高血压患者动态动脉硬化指数（AASI）的影响。方法选取我院2010年1月~2014年1月收治入院的原发性高血压患者200例作为研究对象,随机分为两组。对照组100例应用厄贝沙坦片控制血压,观察组100例患者在此基础上加用黄芪颗粒治疗3个月,治疗前后通过24 h动态血压（24 h ABPM）监测血压,分析血压参数,计算AI。结果两组治疗前白昼血压比较差异无统计学意义（P〈0.05）,治疗后,观察组患者血压水平均明显下降（P〈0.05）,对照组夜间血压水平均明显下降（P〈0.05）;观察组患者夜间动态血压与对照组治疗后比较,血压水平均明显下降（P〈0.05）。两组患者治疗前AI为4.56±2.20,观察组患者治疗后AI为0.48±0.17,明显低于治疗前,差异有统计学意义（P〈0.05）;同时也明显低于对照组的4.13±0.15,差异有统计学意义（P〈0.05）。结论黄芪颗粒能降低原发性高血压患者的AI,值得推广应用。
Objective To explore the impact of astragalus granules on ambulatory arterial stiffness index（AASI） of primary hypertension patients. Methods 200 patients with primary hypertension from January 2010 to January 2014 of our hospital were selected as study object,and patients were randomly divided into two groups.100 patients in control group were treated with irbesartan to control blood pressure.100 patients in observation group were treated with astragalus granules for 3 months on the basis of control group.Before and after treatment,blood pressure was monitored by using24 h ABPM,blood pressure parameter was analyzed and AI was counted. Results There was no significant difference in blood pressure between the two groups before treatment（P〈0.05）.After treatment,blood pressure in the observation group was significantly decreased（P〈0.05）,the control group at night blood pressure levels was significantly decreased respectively（P〈0.05）;the observation group of patients with the night time ambulatory blood pressure and control group after treatment,blood pressure levels was significantly decreased respectively（P〈0.05）.The AI before treatment between two groups was 4.56 ±2.20,the AI after treatment in observation group was 0.48 ±0.17,significantly lower than before treatment,and the difference was statistical significance（P〈0.05）.At the same time,the AI index in observation group obvious lower than that was 4.13±0.15 in control group,and the difference was statistical significance（P〈0.05）. Conclusion Astragalus granules can decrease the ambulatory arterial stiffness index of primary hypertension patients in clinical application,and is worth to promotion and application.
出处
《中国当代医药》
2016年第1期182-184,共3页
China Modern Medicine
关键词
原发性高血压
黄芪胶囊
动态动脉硬化指数
Primary hypertension
Astragalus capsule
Ambulatory arterial stiffness index
