瑞舒伐他汀治疗老年冠状动脉性心脏病合并高脂血症的机制研究被引量：23

下载PDF

导出

摘要目的探讨瑞舒伐他汀治疗冠状动脉性心脏病(CHD)合并高脂血症老年患者的作用机制及应用价值。方法以在该院接受治疗的129例CHD合并高脂血症老年患者为研究对象,分为两组,其中一组接受常规治疗,为对照组;另一组在对照组基础上给予瑞舒伐他汀治疗,为观察组。以2个月为治疗周期,比较两组间治疗前后血脂、超敏C反应蛋白(hs-CRP)、乳脂肪球表皮生长因子8蛋白(MFG-E8)及Klotho水平差异并探讨瑞舒伐他汀的作用机制。结果两组患者在治疗前体内血脂、hsCRP、MFG-E8及Klotho水平差异均无统计学意义(P>0.05)。治疗后两组患者症状均有所改善。与对照组比较,观察组患者血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)水平明显下调,而高密度脂蛋白胆固醇(HDL-C)水平明显上调,差异有统计学意义(P<0.05)。此外,观察组患者体内hs-CRP表达水平均明显低于对照组患者(P<0.05),观察组患者血清中MFG-E8及Klotho水平明显高于对照组,两组患者间差异有统计学意义(P<0.05)。结论瑞舒伐他汀一方面通过降低患者血清中血脂和hs-CRP水平,另一方面通过上调MFG-E8及Klotho水平,有效地治疗CHD合并高脂血症的老年患者。

作者梁嘉晖胡经航韦继政

机构地区广东省江门市五邑中医院恩平分院内科广东省江门市五邑中医院神经内科

出处《重庆医学》 CAS 北大核心 2016年第1期112-114,共3页 Chongqing medicine

关键词瑞舒伐他汀冠心病高脂血症

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献13

1Kones R. Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey[J]. Drug Des Devel Ther,2011,5:325-380.
2Patel S,Celermajer DS, Bao S. Atherosclerosis-underlying inflammatory mechanisms and clinical impllcations[J]. Int J Biochem Cell Biol, 2008,40(4) : 576-580.
3Roth EM, McKenney JM, Kelly MT, et al. Efficacy and safety of rosuvastatin and fenofibric acid combination :herapy versus simvastatin mono therapy in patients withhypercholesterolemia and hypertriglyceridemia[J]. Am J Cardiovasc Drugs,2010,10(3) :175-186.
4Dai W,Li Y, Lv YN, et al. The roles of a novel antiinfl- ammatory factor,milk fat globuleepidermal growth factor 8,in patients with coronary atherosclerotic heart disease [J] Atherosclerosis ,2014,233 (2) : 661-665.
5刘威,康林,曹贵方.血清KLOTHO浓度与冠状动脉粥样硬化性心脏病的关系[J].岭南心血管病杂志,2012,18(5):463-464. 被引量：7
6Ridker PM, MaeFadyen JG,Fonseca FAH, et al. Number needed to treat with rosuvastatin to prevent first cardio- vascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high- sensitivity C-reactive protein: justification for the use of statins in prevention:an intervention trial evaluating rosu- vastatin (JUPITER)[J]. Cite Cardiovasc Qual Outcomes, 2009,2(6):616-623.
7Brown TM, Bittner V. Management of stable patients with coronary heart disease: clinical implications of the clinical out comes utilizing revascularization and aggressive drug evalua tion (COURAGE) trial[J]. J Clin Lipidol, 2007,1 (6) : 564- 574.
8Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/ AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines developed in collaboration with the American Academy of Family Physicians, Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons[J]. J Am Coll Cardiol, 2011,57 (19) : 215 -367.
9Montero-Vega MT. The inflammatory process underlying atherosclerosis[J]. Crit Rev Immunol, 2012,32 ( 5 ) : 373: 462.
10Manduteanu I,Simionescu M. Inflammation in atheroscle- rosis..a cause or a result of vascular disorders? [J]. Cell Mol Med,2012,16(9) :1978-1990.

二级参考文献8

1KURO-O M,MATSUMURA Y,AIZAWA H. Mutation of the mouse KLOTHO gene leads to a syndrome resembling ageing[J].Nature,1997,(6655):45-51.
2KUROSU H,YAMAMOTO M,CLARK J D. Suppression of aging in mice by the hormone KLOTHO[J].Science,2005,(5742):1829-1833.
3ARKING D E,BECKER D M,YANEK L R. KLOTHO allele status and the risk of early-onset occult coronary artery disease[J].American Journal of Human Genetics,2003,(05):1154-1161.
4XIAO N M,ZHANG Y M,ZHENG Q. KLOTHO is a serum factor related to human aging[J].Chinese Medical Journal(Engl),2004,(05):742-747.
5JO S H,KIM S G,CHOI Y J. KLOTHO gene polymorphism is associated with coronary artery stenosis but not with coronary calcification in a Korean population[J].INTERNATIONAL HEART JOURNAL,2009,(01):23-32.doi:10.1536/ihj.50.23.
6IMAMURA A,OKUMURA K,OGAWA Y. KLOTHO gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese[J].Clinica Chimica Acta,2006,(1-2):66-70.
7WANG Y,SUN Z. Current understanding of KLOTHO[J].Ageing Research Reviews,2009,(01):43-51.
8SAITO Y,YAMAGISHI T,NAKAMURA T. KLOTHO protein protects against endothelial dysfunction[J].Biochemical and Biophysical Research Communications,1998,(02):324-329.