摘要
目的观察红霉素治疗婴幼儿重症急性毛细支气管炎(SACB)的疗效。方法 SACB患儿50例分为两组:B组20例,常规治疗;A组30例,加用红霉素治疗。另选择正常健康婴幼儿20例为对照(C)组。观察A、B组临床症状改善及住院时间。ELISA法检测三组血清IL-8和可溶性血管细胞间黏附分子1(sVCAM-1)水平。结果A组临床症状持续时间及住院时间均短于B组(P<0.05)。疾病恢复期,A、B组血清IL-8和SVCAM-1水平均低于急性期(P<0.01和P<0.05),A组低于B组(P<0.05)。结论在常规治疗基础上加用红霉素治疗婴幼儿SACB可明显抑制细胞因子和黏附分子产生,改善临床症状。
Objective To explore the efficacy of erythromycin in treating infants with severe acute capillarity bronchitis（SACB）. Methods Fifty SACB infants were divided into two groups of B （conventional therapy, 20 cases） and A（additional use of erythromycin, 30 cases）. Twenty healthy infants were taken as the controls（group C）. The improvements of clitlical symptoms and hospital stay were compared between groups of A and 13. Serum IL-8 and soluble vascular cell adhesion molecule 1 （sVCAM-1） were detected b.y EL1SA. Results The time of clinical symptoms lasted and hospital stay were shorter in group A than those in group B（P〈0. 05）. In the recovery phase of SACB, serum levels of IL-8 and sVCAM-1 in groups of A and B were lower than those in acute phase（P〈0. 01 and P〈0.05） ,which were lower in group A than those in group B（P〈0.05）. Conclusion On the basis of conventional therapy, additional use of erythromycin can obviously reduce serum levels of cytokines and adhesion molecules and improve clinical symptoms in the infants with SACK
出处
《江苏医药》
CAS
2016年第1期74-75,79,共3页
Jiangsu Medical Journal
