摘要
目的:对利多卡因静脉注射、鼓室给药、穴位注射等不同给药途径治疗耳鸣的文献进行综合评价,评估利多卡因在耳鸣综合治疗中的应用价值。方法:检索中国知网、万方、维普、Pubmed、SciVerse ScienceDirect、Springer、OVID等数据库,筛选出利多卡因治疗耳鸣的文献进行严格质量评价和资料提取,采用Revman5.2软件对文献相关指标进行Meta分析。结果:共纳入文献16篇,1 203例患者,其中中文文献14篇,英文文献2篇。耳鸣患者病程7h^20年,疗效的评估主要依据响度分级、严重程度量表或主观感受。所有文献均未具体提及疗效维持时间,仅以"短期"、"较短"等词加以说明。其中静脉注射组133例,治疗总有效率为73.4%(98例);鼓室给药组50例,总有效率为74.0%(37例);穴位注射组332例,总有效率为87.7%(291例)。各对照组例数分别为125、40和326例,总有效率分别为42.4%、50.0%和58.3%。Meta分析结果显示,利多卡因经3种不同给药方式治疗耳鸣的总有效率均高于传统药物(P<0.05)。结论:利多卡因不同给药途径尽管作用维持时间短,但均有一定耳鸣抑制作用。其作为耳鸣综合治疗的辅助措施,有助于缩短适应耳鸣的时间而非消除耳鸣,临床应用中应注意分析。
Objective：To evaluate the clinical value of lidocain in the treatment of tinnitus through three routes of administration（intravenous,intratympanic and acupoint injection）by analyzing literatures.Method：Articles were collected through Hownet,Wanfang,VIP,Pubmed,SciVerse ScienceDirect,Springer and OVID,etc.The articles were strictly evaluated based on their quality.The Meta-analysis was performed to evaluate the outcomes by RevMan 5.2 software.Result：A total of 16 articles with 1 203 patients were enrolled in the analysis.Their tinnitus history ranged from 7hours to 20 years.Assessment methods include tinnitus loudness levels、severity scales and subjective feelings.None of articles refer to maintaining time,instead of ＂short-term＂, ＂short＂ and so on.A total of 133 cases received intravenous injection and the effective rate was 73.4%（98cases）.50 cases and 332 cases received intratympanic and acupoint injection respectively and their effective rates were 74.0%and 87.7%,respectively.The effective rate ranged from 42.4%to 58.3 %in control group.Meta-analysis results indicate that all three routes of lidocaine administrations are more effective than conventional methods（P〈0.05）.Conclusion：Different routes of lidocaine administration have a good but short time effects on the tinnitus control.It can effectively reduce the time of tinnitus habituation as a complementary treatment.But its value still needs further evaluation.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2016年第2期101-105,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
上海市市级医院新兴前沿技术联合攻关项目任务书(No:SHDC12014125)
上海市市属博士学科点建设基金(No:B201408)
