摘要
氟斑牙是一种世界范围内多个国家流行的地方病,我国是地方性氟中毒发生最严重的国家之一,尤其在西南地区分布更为广泛。牙胚发育过程中机体摄入过量氟而导致釉质发育障碍是氟斑牙的发病原因,但氟斑牙发生的具体机制尚不完全清楚。国内外学者应用多种方法对氟斑牙的分子发病机制进行了研究,近几年来研究重点主要集中在氟对釉基质蛋白及蛋白酶的影响以及通过内质网应激、钙超载引起的细胞凋亡途径等方面。现就上述分子机制研究现状进行以下综述。
Endemic dental fluorosis has been reported in some regions of the world. China seemed to have high prevalence of endemic dental fluorosis, especially in southwest China. It is now most likely that excessive fluoride intake during enamel development play a key role in the pathogenesis of dental fluorosis. However, excessive intake of fluoride-induced cellular and molecular mechanisms of dental fluorosis are not entirely conclusive. Scholars at home and abroad have made a lot of research on pathogenesis of enamel fluorosis by using various experimental techniques. More recent studies mainly suggest that endoplasmic reticulum stress and calcium overload-associated apoptotic pathway may participate in fluoride excess-evoked pathogenesis of dental fluorosis. Furthermore, the functional changes of enamel matrix protein and protease activity may be involved in the pathological event. This paper summarized the recent research progress on this topic.
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2016年第1期71-74,共4页
Chinese Journal of Endemiology
基金
贵州省第六批科技创新人才团队建设项目([2013]4026号)
贵州省高等学校重点学科建设项目(SZXK-201207-04)
贵州省高等学校特色重点实验室建设项目(黔教合KY字[2013]109号)
省市科技合作专项资金项目(省市科合[2014]41号)
关键词
氟
氟中毒
牙
分子作用机制
Fluorine
Fluorosis, dental
Molecular Mechanisms of Action