摘要
目的评价维生素E治疗不明原因男性不育的有效性。方法检索Pubmed、Embase、中国生物医学文献数据库（CBM）,检索时间为1995年1月至2015年8月。纳入关于维生素E治疗不明原因男性不育的所有随机对照试验,质量评价后采用Rev Man 5.3软件进行meta分析。结果共纳入6个随机对照试验共408例患者,维生素E治疗能改善不明原因男性不育患者的妊娠率[P〈0.05,相对危险度（OR）=3.55,95%可信区间（95%CI）1.80~6.98]、精子活力（P〉0.05,OR=1.36,95%CI 0.30~6.15）和精子浓度（P〉0.05,OR=2.04,95%CI 0.41~10.11）。结论维生素E治疗可以提高不明原因男性不育的妊娠率,对精子活力、浓度无明显影响,但上述结论尚需大样本的随机对照试验进一步验证。
Objective To evaluate the effectiveness of vitamin E for treating unexplained male infertility. Methods Pubmed ,Embase and Chinese biomedicine（CBM） were retrieved from January 1995 to August 2015. All the randomized controlled trials （RCT） on vitamin E for treating unexplained male infertility were included. After the quality evaluation ,the meta analysis was performed by using the Revman 5.3 software. Results 6 RCT were included,involving 408 patients,the pregnancy rate was improved by the vitamin E therapy [P〈0.05 ,relative risk （OR）=3.55,95% CI 1.80-6.98], semen motility improvement （P〉0.05, 0R=1.36,95%CI0.30-6.15） and the semen concentration improvement （P〉0.05,0R=2.04,95%CI 0.41-10.11）. Conclusion Vitamin E might improve the pregnancy rate in unexplained male infertility and has no influence on sperm motility and concentration. But this conclusion still needs large-sample RCT for further verification.
出处
《现代医药卫生》
2016年第2期178-180,184,共4页
Journal of Modern Medicine & Health
