摘要
目的 考察合用β-内酰胺酶抑制剂舒巴克坦（ＳＢＴ）前后头孢哌酮（ＣＰＺ）对４种致病菌抗生素后效应（ＰＡＥ）的变化。方法 采用特异性β-内酰胺酶鉴定试剂Ｎｉｔｒｏｃｅｆｉｎ挑选大肠埃希氏杆菌、金黄色葡萄球菌、变形杆菌和绿脓假单胞菌的产酶菌株，用比浊法测定受试菌株在不同ＣＰＺ浓度时的ＰＡＥ值。结果 合用ＳＢＴ后，ＣＰＺ对产酶菌株的ＰＡＥ均有不同程度的延长，低浓度时（１／２，１倍ＭＩＣ）ＰＡＥ增加更明显（Ｐ＜０．０５）。结论 合并ＣＰＺ和ＳＢＴ的给药方案对治疗产β-内酰胺酶菌株引起的感染有利，尤其在体内药物浓度较低时，合并用药可以更长时间地抑制细菌生长。
Aim The postantibiotics effects (PAEs) induced by cefoperazone (CPZ) alone were to be compared with those induced by a 1: 1 combination of CPZ and sulbactam(SBT) Methods All the clinical isolates selected, including every six isolates of E. coli, S. aureus, Proteus and P. aeruginosa, were proved to be beta- lactamase- producing strains by the Nitrocefin Test. The PAEs were determined by means of measurement of transmittance using AVANTAGE Microbiology System. Results Longer PAEs induced by the combination of CPZ and SBT were observed in each concentration, even in lower CPZ concentrations (1/2 and 1 MIC), the PAEs were significant longer than by CPZ alone. Conclusion The results suggest that the efficacy of CPZ combined with SBT is stronger than that of CPZ alone against the infections caused by beta - lactamase - producing isolates.
关键词
舒巴克坦
头孢哌酮
体外抗生素后效应
cefoperazone
sulbactam
postantibiotic effect
beta - lactamase
