摘要
目的探讨脐带间充质干细胞（UC-MSC）移植治疗系统性红斑狼疮（SLE）患者的临床疗效与安全性。方法选取2013年5月—2014年4月长江大学附属第一医院诊治的SLE患者18例,分别予以2次UC-MSC（剂量为5×10~7个/次）移植治疗,评价治疗前后患者临床症状、体征及各实验室指标的变化。结果 UC-MSC移植治疗后1个月,大多数患者临床症状及体征较移植前得到明显改善,其中发热、疲倦、乏力等一般情况好转15例（83.3%）,皮疹减轻11例（61.1%）,血管炎改变较前好转9例（50.0%）,关节痛减轻5例（27.8%）。UC-MSC移植治疗0.5个月后,18例患者SLE疾病活动评分（SLEDAI）较移植前降低（P〈0.05）,1个月后降低更为明显（P〈0.01）。与治疗前比较,移植治疗1个月后,24 h尿蛋白定量（UAER）、血清Alb、补体C3等指标均有所改善（P〈0.05）,移植后3个月更明显（P〈0.01）;移植治疗2个月、3个月后,血清肌酐（SCr）水平较移植前均有明显下降,血清C4较移植前明显升高（P〈0.01）。所有患者均未见与移植相关的发热、过敏等不良反应。结论 UC-MSC移植治疗SLE,其疗效肯定,且较为安全,在临床上具有十分广阔的应用前景,但其远期疗效尚需进一步观察随访。
Objective To investigate the clinical efficacv and safety of umbilical cord mesenchymal stem cells（UCMSC） in the treatment of patients with systemic lupus erythematosus（SLE）.Methods Selected 18 cases of SLE patients from May 2013 to April 2014 who treated in First Affiliated Hospital of Yangtze University,they were treated by two time of UC-MSC（at a dose of 5 × 10~7 /time） transplantation,and evaluated before and after treatment,patient＇s clinical symptoms,signs,and the laboratory indexes changes.Results After one month of UC-MSC transplant treatment,most patient s clinical symptoms and signs improved significantly compared than before transplantation,including fever,fatigue,weakness and other general situation improved in 15 cases（83.3%）,rash mitigate in 11（61.1%）,vasculitis changes belter than before in nine cases（50.0%）,arthralgia mitigate in five cases（27.8%）.After 0.5 months of UC-MSC transplant treatment,18 patients SLE disease activity score（SLEDAI） reduced compared with before transplantation（P〈0.05）,after one month,the effect was more obvious（P〈0.01）;and compared with before treatment,after one month of treatment,24 h urinary protein excretion（UAER）.serum Alb,complement C3 and other indicators have improved（P〈0.05）,three months after transplantation,the effect was more obvious（P〈0.01）;after two months and three months transplantation treatment,serum creatinine（SCr） levels decreased significantly than before treatment,serum C4 was significantly higher than that before transplantation（P〈0.01）.All patients had no fever,allergies and other adverse reactions associated with transplantation.Conclusion UC-MSC transplantation in the treatment of SLE is efficacv and relative!） sale,it has a very broad application prospects in clinical,but its long-term efficacy is still need to be further observed.
出处
《疑难病杂志》
CAS
2016年第1期44-47,共4页
Chinese Journal of Difficult and Complicated Cases
关键词
脐带间充质干细胞
系统性红斑狼疮
移植
Umbilical cord mesenchymal stem cells
Systemic lupus erythematosus
Transplantation
