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华法林与阿司匹林预防老年房颤患者脑卒中的系统评价 被引量:9

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摘要 目的评价华法林与阿司匹林预防老年房颤患者脑卒中疗效及安全性。方法检索Pub Med、Cochrane、Embase、CNKI、VIP和CBM数据库,收集公开发表的华法林与阿司匹林预防老年房颤患者脑卒中比较的随机对照试验(RCT),利用Rev Man 5.2.7软件进行Meta分析。结果最终纳入23个RCT,共4931例老年房颤患者(≥60岁)。Meta分析结果 :华法林预防脑卒中的疗效优于阿司匹林;两药发生严重或致死性出血不良反应无明显差异,但单独对中国老年患者进行分析,华法林风险高于阿司匹林。结论华法林能有效预防老年房颤患者脑卒中,但在中国人中应关注其引起的严重出血问题。
出处 《西南国防医药》 CAS 2016年第1期72-75,共4页 Medical Journal of National Defending Forces in Southwest China
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