摘要
目的:探讨溶血磷脂酸(lysophosphatidic acid,LPA)、恶性肿瘤特异性生长因子(tumor specific growth factor,TSGF)和糖类抗原125(cancer antigen 125,CA125)联合检测对卵巢癌诊断的临床应用价值。方法:对108例卵巢癌和43例卵巢良性肿瘤和50例健康女性体检者的血清中LPA、TSGF和CA125进行测定,分析肿瘤标志物联合检测对卵巢癌的诊断价值。结果:卵巢癌组LPA、TSGF和CA125水平均显著高于良性卵巢肿瘤组和正常对照组(P均<0.01);LPA、TSGF和CA125联合检测的灵敏度和特异度高于单项和两两联合检测。结论:肿瘤标志物联合检测可提高对卵巢癌诊断的准确性,对卵巢癌的鉴别诊断提供可靠的实验依据。
Objective：To investigate the value of LPA,TSGF and CA125 in the diagnosis of ovarian cancer. Methods ：The serum levels of LPA ,TSGF and CA125 in 108 cases of ovarian cancer and 42 cases of benign ovarian tumor and 50 healthy female volunteers were measured to observe the combined detection of tumor markers in the diagnosis of ovarian cancer. Results：LPA, TSGF and CA125 in ovarian cancer group were significantly higher than those of benign ovarian tumor group and normal control group（ P 〈 0.01 ）. Sensitivity and specificity of the combined detection in LPA,TSGF and CA125 were higher than individual detection and two joint detection. Conclusion：The combined detection of tumor markers can improve the accuracy of diagnosis and the differential diagnosis of ovarian cancer.
出处
《现代肿瘤医学》
CAS
2016年第3期457-459,共3页
Journal of Modern Oncology
