摘要
目的分析血清内脏脂肪特异性丝氨酸蛋白酶抑制剂(visceral adipose tissue-derived serine protease inhibitor,vaspin)浓度检测在冠状动脉粥样硬化性心脏病(冠心病)临床诊断及病情程度评估中的价值。方法采用冠状动脉造影术检测70例冠心病患者病变程度,采用酶联免疫吸附法(ELISA)检测冠心病患者和67例对照组患者血清vaspin浓度,比较各病变积分组患者的血清vaspin浓度。采用Logistic回归法分析血清vaspin浓度与冠心病的相关性。结果观察组血清总胆固醇、低密度脂蛋白胆固醇浓度及糖尿病发生率均明显高于对照组,差异有统计学意义(P<0.05);血清vaspin浓度明显低于对照组,差异有统计学意义(P<0.05)。经Logistic回归分析,血清vaspin浓度过低是冠心病发病的独立危险因素(尸<0.05)。随着冠状动脉病变积分增加,血清vaspin浓度呈明显降低趋势(P<0.05)。结论血清vaspin浓度检测在冠心病临床诊断及病情程度评估中具有重要的临床价值。
Objectives To explore the value of serum concentration of visceral adipose tissue-derived serine protease inhibitor （vaspin） on clinical diagnosis and evaluation of pathogenetic condition in patients with coronary artery disease （CAD）. Methods Totally 70 patients with CAD was performed coronary angiography to evaluate the severity of CAD. Serum concentrations of vaspin in CAD group and control group （n=67） were detected by enzyme-linked immunosorbent assay （ELISA）. Scores of coronary artery lesion, serum concentrations of vaspin were compared between the two groups. Correlation of serum concentrations of vaspin and CAD was analyzed by Logistic regression method. Results Serum concentrations of total cholesterol （TC）, low density lipoprotein-eholesterol （LDL-C） and incidence of diabetes were significantly higher in DAD group than in control group （P〈0.05） ; serum concentration of vaspin was lower in CAD group than in control group （P〈0.05）. Serum concentration of vaspin decreased as score of coronary lesion increased （P〈0.05）. Logistic regression indicated that, decreasing of serum concentration of vaspin was an independent risk factor of CAD （P〈0.05）. Conclusions Serum concentration of vaspin play an important role in clinical diagnosis and evaluation of pathogenetic condition in patients with CAD.
出处
《岭南心血管病杂志》
2016年第1期38-41,共4页
South China Journal of Cardiovascular Diseases
关键词
冠状动脉疾病
内脏脂肪特异性丝氨酸蛋白酶抑制剂
心绞痛
心肌梗死
coronary artery disease
visceral adipose tissue-derived serine protease inhibitor
angina pectoris
myocardial infarction
