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非体外循环下冠脉搭桥术的冠心病合并糖尿病患者麻醉管理及治疗效果 被引量:18

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摘要 目的非体外循环下冠脉搭桥术(OPCABG)的冠心病(CHD)合并糖尿病患者麻醉管理及临床治疗效果分析。方法 CHD伴糖尿病患者92例中将接受OPCABG的49例设为观察组,接受体外循环冠状动脉搭桥术(CCABG)的43例作为对照组。结果观察组平均血压(MBP)显著低于对照组(t=3.155,P=0.002)。观察组动脉血氧含量(Pa O2)显著高于对照组(t=9.394,P<0.001);观察组术前、中、后中心静脉压(CVP)(F=188.1,P<0.001)、平均动脉压(MAP)(F=30.96,P<0.001)差异显著;术中MAP水平、CVP水平显著高于术前准备和分别低或高于胸腔缝合后(P<0.05);观察组手术时间(t=16.42,P<0.001)、失血量(t=7.310,P<0.001)、支架数目(t=3.309,P=0.001)、术后24 h引流量(t=11.570,P<0.001)水平显著高于对照组;观察组血清中血肌酐(Cr)(t=2.691,P=0.009)、白细胞介素(IL)-6(t=7.974,P<0.001)、IL-8(t=9.943,P<0.001)和IL-10(t=3.241,P=0.002)显著高于对照组;观察组血清中IL-10与IL-6呈现正相关(r=0.322,P=0.024),IL-10与IL-8呈现显著正相关(r=0.491,P<0.001);利用Kaplan-Meier法分析生存情况发现,观察组较对照组生存率明显提高(93.88%,46/49 vs 76.74%,33/43;Log-rankχ2=3.909,P=0.048)。结论 OPCABG加强麻醉管理可以降低前负荷,控制心率,维持血流动力学稳定。OPCABG可以减少手术创伤和并发症的发生,降低体外循环引起的炎症反应对心肌的损伤,患者预后良好。
作者 杜守峰
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第3期666-668,共3页 Chinese Journal of Gerontology
基金 河南省科技厅项目(No.122102310076)
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