摘要
目的讨论两种化疗方案治疗恶性滋养细胞肿瘤的临床疗效。方法选取2013年1月-2014年12月在该院进行恶性滋养细胞肿瘤治疗患者63例进行回顾性分析,按照化疗方案分为EP组38例和5-FU+KSM组25例。观察患者经过治疗完全缓解的例数,及手术切除子宫患者所占比例。观察两组患者副作用发生情况。结果两组患者疗效比较,EP组患者完全缓解比例略高28例,占73.68%;5-FU+KSM组完全缓解18例,占72%。5-FU+KSM组手术比例略高,手术切除子宫8例,占32%;EP组手术切除12例,占31.58%,但两组数据差异均无统计学意义(均P>0.05)。胃肠反应、口腔溃疡、肝肾毒性、腹泻等副作用EP组明显低于5-FU+KSM组,差异有统计学意义(P<0.05)。白细胞减少、脱发、血红蛋白下降、血小板减少等副作用两组数据差异无统计学意义(P>0.05)。结论两种化疗方案在临床疗效上差异无统计学意义,但EP组在部分化疗副作用方面明显小于5-FU+KSM组。
Objective To explore the clinical effects of two kinds of chemotherapy regimens in treatment of malignant trophoblastic tumor. Methods Sixty-three patients with malignant trophoblastic tumor treated in the hospital from January 2013 to December 2014 were selected and analyzed retrospectively, then the patients were divided into EP group （38 patients） and 5-FU＋KSM group （25 patients） . Tile numbers of patients of remission after treatment, proportions of patients treated by hysterectomy, and adverse reactions in the two groups were observed. Results The complete remission rates in EP group and 5-FU＋KSM group were 73.68% （28 patients） and 72.00% （ 18 patients）, respectively. The rates of hysterectomy in 5-FU＋KSM group and EP group were 32. 00% （8 patients） and 31.58% （ 12 pa- tients）, respectively, but there was no statistically significant difference between the two groups （P〉0.05） . The incidence rate of adverse reactions （gastrointestinal reaction, oral ulcer, liver and kidney toxicity, diarrhea） in EP group was statistically significantly lower than that in 5-FU＋KSM group （ P〈0.05 ） . There was no statistically significant difference in the incidence rates of aleueocytosis, lipsotrichia, hemo- globin decrease, and thrombocytopenia between the two groups （P〉O. 05） . Conclusion There was no statistically significant difference in clinical effect between the two kinds of chemotherapy regimens, but the adverse reactions of chemotherapy in EP group were less than those in 5-FU＋KSM group.
出处
《中国妇幼保健》
CAS
2016年第3期625-627,共3页
Maternal and Child Health Care of China
基金
新疆维吾尔自治区科学技术厅(2012211A044)
