摘要
目的探索建立与改进盐酸米诺环素微生物限度检查方法。方法采用低速离心、薄膜过滤和中和剂法联用的方法去除盐酸米诺环素的抗菌活性。结果本方法满足中国药典2010年版微生物方法学验证的基本要求。结论本方法可作为盐酸米诺环素的微生物限度检查方法。
OBJECTIVE To explore and establish the method of microbial limit examination of minocycline hydrochloride. METHODS Antibacterial activity was examed by the combined use of low-speed centrifugal method,membrane filtration and neutralization agent method removal of minocycline hydrochloride. RESULTS The method can meet the basic requirements of verification China Pharmacopoeia 2010 microbial method. CONCLUSION This method can be used as a method for microbial limit test of·minocycline hydrochloride.
出处
《海峡药学》
2015年第12期59-62,共4页
Strait Pharmaceutical Journal
关键词
盐酸米诺环素
微生物限度
低速离心
薄膜过滤
中和剂
Minocycline hydrochloride
Microbial limit
Centrifuging
Membrane filtration
Neutralizer
