摘要
目的评价^(90)Sr/^(90)Y外照射治疗带状疱疹的临床疗效及不良反应。方法将129例带状疱疹患者分为外照射和药物治疗两组。外照射治疗组(69例)按常规敷贴治疗,每日一次,3~5天为一个疗程,总剂量为1600~3600 c Gy/野。药物治疗组(60例)口服阿昔洛韦片0.2g/次,每日5次,外用阿昔洛韦软膏,每日2次,7天为一个疗程。1个疗程后观察两组患者的临床疗效和不良反应。结果^(90)Sr/^(90)Y外照射治疗组痊愈55例,显效10例,总有效率94.20%;阿昔洛韦对照组痊愈25例,显效17例,总有效率70.00%。χ2检验得两组总有效率的差异有统计学意义(χ2=13.2^(90),P<0.001)。不良反应比较,两组不良反应发生率分别为18.84%、21.67%,差异无统计学意义(χ2=0.159,P>0.05)。结论^(90)Sr/^(90)Y外照射治疗带状疱疹是一种安全、简便、治愈率高、痛苦少的有效方法。
Objective To evaluate the clinical efficacy and adverse reaction of 90Sr/90Y applicator brachytherapy in patients with herpes zoster. Methods 129 patients with herpes zoster were assigned to receive either 90Sr/90Y applicator brachytherapy or Aciclovir drug therapy. The brachytherapy group （N = 69）were treated once a day, 3 -5 times in a course with total doses from 1600cGy to 3600cGy. The drug therapy group（ N = 60）were treated with Aciclovir tablets, usual dose was 0.2g, 5 times per day for 7 days, combined with Acyclovir ointment for external use. The clinical efficacy and adverse reactions of patients from both groups after or/e course were observed. Results The rate of cure and obvious efficiency in brachytherapy group was 94.2% in total, while the rate was 70.0% in drug therapy group, with significant difference （X2 = 13. 290, P 〈 0. 001 ）. The rate of adverse reactions in the two groups were 18.84% and 21.67% ,without significant difference （x2 = 0. 159 ,P 〉 0.05 ）. Conclusion The 90Sr/90Y applicator brachytherapy is safe, simple and painless in the treatment of herpes zoster with high effectiveness and efficiency.
出处
《标记免疫分析与临床》
CAS
2016年第1期47-49,共3页
Labeled Immunoassays and Clinical Medicine
