摘要
长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200个核苷酸、没有编码蛋白能力的RNA,通常被认为是一类异构体RNA。近年来,越来越多的研究表明,lncRNA在许多重要的生物作用及人类疾病发展中起关键作用。lncRNA作为调节因子参与基因表达调控的各个层次,在表观遗传、转录调控及转录后调控等方面有着广泛功能。研究结果已表明,lncRNA表达水平的紊乱与人类各种癌症及其他疾病有很大的关系。作为基因调控网络的调控因子,lncRNA被越来越多的研究者所关注。相较于人类医学,lncRNA在畜禽上的研究尚处于起步阶段。作者对lncRNA的特点、分类、作用机制、研究方法及其在畜禽生长调控方面的研究进展进行了综述,并对其在畜禽养殖中的应用进行了展望,以期为lncRNA在畜禽生长调控方面开展深入研究提供理论基础。
Long non-coding RNA（lncRNA）are non-protein coding transcripts longer than 200 nucleotides that are usually considered collectively as a heterogeneous class of RNA.Recently,an increasing number of studies have shown that lncRNA have a pivotal role in various critical biological processes and a number of complex human diseases.lncRNA act as regulators at different levels of gene expression including chromatin organization,transcriptional regulation,and posttranscriptional control.lncRNA expression disorder has been found to be associated to cancer and other human disease.As functional molecules,lncRNA have attracted more and more researchers attention.Compared to human medicine,it is still at the initial stage of lncRNA application in livestock studies.In the present study,the characteristics,classification,acting mechanisms,methods for lncRNA analysis,as well as research progress in growth regulation of livestock of lncRNA are reviewed,and prospect the application of lncRNA in livestock breeding,in order to provide the theory foundation for thorough study of lncRNA in growth regulation of livestock.
出处
《中国畜牧兽医》
CAS
北大核心
2016年第1期197-203,共7页
China Animal Husbandry & Veterinary Medicine
基金
国家自然基金(31072152
31472217)
关键词
长链非编码RNA
基因调控
作用机制
畜禽
研究进展
long non-coding RNA（lncRNA）
gene regulation
acting mechanism
livestock
research progress
