摘要
目的探讨血管内皮生长因子(VEGF)表达与鼻咽癌患者临床病理特征的关系,为鼻咽癌诊治提供理论依据。方法收集85例临床资料完整的鼻咽癌组织切片以及40例正常的鼻咽组织切片,采用免疫组织化学染色(SP)法检测标本中VEGF的表达情况,分析鼻咽癌组织切片中VEGF的表达与年龄、性别、TNM分期及有无复发等病理特征的关系。结果VEGF阳性表达主要位于细胞质内。鼻咽癌组织切片中VEGF阳性表达72例(85%),正常鼻咽组织切片中VEGF阳性表达3例(8%),鼻咽癌组织中VEGF阳性表达率明显高于正常鼻咽组织(P<0.05)。不同年龄及性别鼻咽癌患者VEGF阳性表达率比较差异均无统计学意义(P均>0.05),而不同TNM分期及复发情况患者阳性表达率比较差异有统计学意义(P均<0.05)。结论 VEGF在鼻咽癌切片组织中阳性表达率较高,其表达率与肿瘤TNM分期、有无复发有明显的关系,检测VEGF表达情况能为鼻咽癌诊治提供理论依据。
Objective It is to observe the expression of vascular endothelium growth factor （VEGF） in nasopharyngeal carcinoma （NPC） , and investigate the relationships of VEGF with the clinical pathological features, in order to provide the theory for treats NPC. Methods 85 cases of nasopharyngeal carcinoma tissues section of patients with complete clinical data and 40 cases of normal nasopharyngeal tissues section were collected and the expression of VEGF in them were detected by immunohisto-chemistry （SP） method. The relationship of VEGF expression with the clinical pathological features included age, sex, TNM stage and recurrence in NPC tissue were analyzed. Results The positive expression of VEGF in NPC was observed mainly in cytoplasm of cells. There were 72 cases （85%） of nasopharyngeal carcinoma and 3 cases （8%） of normal tissues with positive express of VEGF, the positive expression rate of VEGF in NPC tissues was significantly higher than that in normal nasopharyngeal tissues （P 〈 0.05）. There were no significant difference in the positive expression of VEGF in NPC tissue between different age and sex （ all P 〉 0.05） , but were significant difference between different TNM stages and recurrence state （all P 〈 0.05 ）. Conclusion The positive expression rate of VEGF in NPC tissue is higher, and it has relationship with TNM stage and recurrence. The detection of VEGF expression can provide a theoretical basis for the diagnosis and treatment of NPC.
出处
《现代中西医结合杂志》
CAS
2016年第3期245-247,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
血管内皮生长因子
鼻咽癌
血管形成
血管通透性
肿瘤TNM分期
vascular endothelium growth factor
nasopharyngeal carcinoma
angiogenesis
vascular permeability
TNM stage
