摘要
目的评价血内毒素在脓毒症病人中的应用价值。方法前瞻性观察收入ICU的脓毒症危重病人36例,检测病人血内毒素、血白细胞、血C反应蛋白、血降钙素原,分析血内毒素与血白细胞、血C反应蛋白、血降钙素原、胃肠道功能障碍之间的关系。结果脓毒症休克患者死亡率较非休克患者死亡率显著增高(P<0.05),且休克组患者内毒素水平较非休克组患者显著增高(P<0.05)。两组患者血内毒素水平血内毒素与病人发生胃肠功能障碍、全血白细胞计数、C反应蛋白之间相关性无统计学意义(均P>0.05);而与降钙素原之间相关性有统计学意义(r=0.462,P=0.039)。结论脓毒症患者一旦发生休克则预后不良风险显著增加,脓毒症患者血浆内毒素水平与休克发生、血浆降钙素原有关。
Objective To estimate the clinical application of plasmic endotoxin detection in the treatment of sepsis. Methods 36 septic patients admitted in our intensive care unit were observed prospectively. The endotoxin, white blood cell, C - reaction protein and procalcitonin were detected. After that, the relationships between endotoxin and white blood cell, C - reaction protein, procalcitonin, gastrointestinal dysfunction respectively were analyzed. Resuits The mortality and the endotoxin level were both higher in patients with septic shock than those in the septic patients without septic shock （ P 〈 0. 05 ）. There were no significantly statistical differences between endotoxin concentration and gastrointestinal dysfunction, white blood ceils, or C - reaction protein respectively （P 〉 0. 05 ）. However, there was statistically difference between endotoxin concentration in plasma and procalcitonin （ r = 0. 462, P = 0. 039）. Conclusion The risk of poor prognosis is larger while shock occurs in the septic patients. Endotoxin is related to shock and serum procalcitonin.
出处
《现代医院》
2016年第1期19-21,共3页
Modern Hospitals
基金
广东省医学科研基金(编号:A2014830)
梅州市科技计划项目(编号:2014B103)
