摘要
目的探讨奥美拉唑治疗小儿消化性溃疡的临床效果及安全性。方法选择我院2014年2月至2015年2月收治的56例消化性溃疡患儿为研究对象,随机分为两组各28例。对照组给予克拉霉素联合阿莫西林治疗,观察组给予克拉霉素、阿莫西林、奥美拉唑联合治疗,比较分析两组的临床疗效及安全性。结果观察组治疗后总有效率为96.43%,显著高于对照组的71.43%(P<0.05)。观察组治疗后Hp根除率及溃疡愈合率分别为89.29%、96.43%,均显著高于对照组的64.29%、75.00%(P<0.05)。观察组与对照组治疗后不良反应发生率分别为17.86%、21.43%,组间无统计学差异(P>0.05)。结论采取奥美拉唑三联法治疗小儿消化性溃疡的疗效显著,安全性高,能促进溃疡面愈合,提高Hp根除率,利于远期预后,值得推广。
Objective To explore the clinical efficacy and safety of omeprazole for the treatment of children with peptic ulcer.Methods Fifty-six cases of children with peptic ulcer admitted to our hospital from February 2014 to February 2015 were selected as research objects, and randomly divided into two groups, with 28 cases in each group. The control group was treated with clarithromycin combined with amoxicillin, while the observation group was treated with clarithromycin, amoxicillin and omeprazole. The clinical effect and safety were analyzed and compared between two groups. Results The total effective rate after treatment of observation group was 96.43%,significantly higher than 71.43% of control group（P〈0.05）. The Hp eradication rate and ulcer healing rate of observation group were89.29% and 96.43% respectively, significantly higher than 64.29% and 75.00% of control group, respectively（both P〈0.05）. The incidence rates of adverse reactions of observation group and control group were 17.86% and 21.43% respectively, with no statistical difference（P〉0.05）.Conclusions Omeprazole triple-united therapy for pediatric peptic ulcer has significant efficacy and high safety. It is conducive to long-term prognosis by promoting the healing of ulcer, and improving the Hp eradication rate.
出处
《临床医学工程》
2016年第1期52-53,共2页
Clinical Medicine & Engineering
