期刊文献+

保乳术联合术后放疗在年轻女性早期乳腺癌患者中的应用价值 被引量:10

Application value of breast-conserving surgery combined with postoperative radiotherary for young women with early-stage breast cancer
下载PDF
导出
摘要 目的探讨保乳术联合术后放疗在年轻女性早期乳腺癌患者中的应用价值。方法 120例年轻女性早期乳腺癌患者,年龄均≤40岁,试验组48例接受患侧乳腺区段切除术加腋窝淋巴结清扫术,术后均辅助放疗;对照组72例接受患侧乳腺癌改良根治术。评价术后1年美容效果,观察两组患者术后5年死亡率和局部复发率、远处转移率。结果试验组与对照组术后5年死亡率、局部复发率和远处转移率分别为2.08%、4.17%、6.25%和2.78%、4.17%、6.94%,两组比较,差异无统计学意义(P>0.05),而试验组乳房外观美容效果优于对照组(P<0.01)。结论保乳术联合术后放疗治疗年轻女性早期乳腺癌患者,与改良根治术相比,不增加死亡率、局部复发率及远处转移率,术后能够获得良好的美容效果。 Objective To investigate the application value of breast-conserving surgery combined with postoperative radiotherapy for young women with early-stage breast cancer. Methods A total of 120 young women (age ≤ 40 years) with early-stage breast cancer were divided into two groups. Forty-eight patients in the experimental group underwent partial mastectomy of the affected side combined with axillary-lymph-node dissection, and received adjuvant radiotherapy postoperatively. Seventy-two patients in the control group received modified radical mastectomy. The postoperative cosmetic efficacy was evaluated one year after surgery. The 5-year mortalities as well as the incidences of local recurrence and distant metastasis were compared between two groups. Results The 5-year mortalities, incidences of local recurrence and distant metastasis of experimental group and control group were 2.08% vs. 2.78% ,4.17% vs. 4.17% and 6.25% vs. 6.94%, respectively, and no statistically significant difference was found between two groups ( P 〉 0.05 ). The postoperative cosmetic efficacy in the experimental group was superior to that in the control group (P 〈 0.01 ). Conclusion For young women with early-stage breast cancer, breast-conserving surgery combined with postoperative radiotherapy might not increase the mortality as well as the incidences of local recurrence and distant metastasis ,and it can obtain better postoperative cosmetic efficacy.
出处 《广西医学》 CAS 2015年第12期1753-1756,共4页 Guangxi Medical Journal
基金 广东省惠州市科技计划项目(2014Y036)
关键词 乳腺癌 早期 保乳术 术后放疗 年轻 局部复发率 远处转移率 死亡率 美容效果 Breast neoplasm Early-stage Breast-conserving surgery Postoperative radiotherapy Young Incidence of local recurrence Incidence of distant metastasis Mortality Cosmetic efficacy
  • 相关文献

参考文献17

  • 1张保宁,邵志敏,乔新民,李波,姜军,杨名添,王水,宋三泰,张斌,杨红健.中国乳腺癌保乳治疗的前瞻性多中心研究[J].中华肿瘤杂志,2005,27(11):680-684. 被引量:247
  • 2Rapiti E, Fioretta G, Verkooijen HM, et al. Survival of young and older breast cancer patients in Geneva from 1990 to 2001 [J]. Eur J Cancer,2005,41 (10) :1 446 - 1 452.
  • 3杨名添,戎铁华,黄植蕃,曾灿光,龙浩,傅剑华,林鹏,王欣,王思愚,王曦,唐军.可手术乳腺癌6263例临床分析[J].癌症,2005,24(3):327-331. 被引量:46
  • 4Gennari R, Curigliano G, Rotmensz N, et al. Breast carcino- ma in elderly women : features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients [ J ]. Cancer, 2004, 101 ( 6 ) : 1 302-1 310.
  • 5Han W, Kim SW, Park IA, et al. Young age : an independent risk factor for disease-free survival in women with operable breast cancer[ J]. BMC Cancer,2004,4:82.
  • 6Cancello G, Maisonneuve P, Rotmensz N, et al. Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women( <35 years) with operable breast canc- er[ J]. Ann 0ncol,2010,21 (10) : 1 974 - 1 981.
  • 7Chia KS, Du WB, Sankaranarayanan R, et al. Do younger fe- male breast cancer patients have a poorer prognosis? Results from a population-based survival analysis [ J ]. Int J Cancer, 2004,108 (5) :761 - 765.
  • 8Liedtke C, Rody A, Gluz O, et al. The prognostic impact of age in different molecular subtypes of breast cancer [ J ]. Breast Cancer Res Treat,2015,152 (3) :667 - 673.
  • 9Vila J, Gandini S, Gentilini O. Overall survival according to type of surgery in young ( ≤ 40 years) early breast cancer patients:A systematic meta-analysis comparing breast-con- serving surgery versus mastectomy [ J ]. Breast, 2015, 24 (3) :175 -181.
  • 10Moran MS, Schnitt SJ, Giuliano AE, et al. Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole- breast irradiation in stages Ⅰ and Ⅱ invasive breast cancer[J]. Int J Radiat Oneol Biol Phys,2014,88(3) :553 -564.

二级参考文献33

  • 1Nab HW, Hop WC, Crommelin MA, et al. Changes in long term prognosis for breast cancer in a Dutch cancer registry[J]. BMJ, 1994,309(6947): 83-86.
  • 2Rutqvist LE, Wallgren A, Nilsson B. Is breast cancer a curable disease? A study of 14,731 women with breast cancer from the Cancer Registry of Norway [J]. Cancer, 1984,53(8): 1793-1800.
  • 3Roses DF. Breast Cancer [M]. New York: Churchill livingstone, 1999: 312.
  • 4Maddox WA, Carpenter JT Jr, Laws HL, et al. A randomized prospective trial of radical (Halsted) mastectomy versus modified radical mastectomy in 311 breast cancer patients [J].Ann Surg, 1983,198(2) :207-212.
  • 5Turner L, Swindell R, Bell WG, et al. Radical versus modified radical mastectomy for breast cancer [J]. Ann R Coil Surg Engl, 1981,63(4) :239-243.
  • 6Martin JK Jr, van Heerden JA, Taylor WF, et al. Is modified radical mastectomy really equivalent to radical mastectomy in treatment of carcinoma of the breast? [J]. Cancer, 1986,57(3) :510-518.
  • 7Early Breast Cancer Trialists Collaborative Group. Effects of radiotherapy and surgery in early breast cancer [J]. N Engl J Med, 1995,333(22): 1444-1455.
  • 8Early Breast Cancer Trialists' Collaborative Group.Polychemotherapy for early breast cancer: an overview of the randomised trials [J]. Lancet, 1998,352(9132) :930-942.
  • 9Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomized Trials[J]. Lancet, 1998,351(9114): 1451-1467.
  • 10Fisher B, Jeong JH, Bryant J, et al. Treatment of lymphnode-negative, oestrogen-receptor-positive breast cancer: long term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials [J]. Lancet, 2004,364 ( 9437 ): 858-868.

共引文献1468

同被引文献106

引证文献10

二级引证文献102

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部