摘要
目的了解儿童急性白血病(AL)患儿TORCH感染和EB病毒感染状况。方法选取经骨髓细胞形态检测确诊的120例新发急性淋巴细胞性白血病(ALL)和50例急性髓细胞白血病(AML)患儿为研究对象,收集患儿血清TORCH、EB病毒免疫球蛋白M(IgM)抗体检测结果,和患儿外周血白细胞计数结果,分白血病类型及年龄组与正常对照组进行分析。结果 ALL患儿120例(70.59%),AML患儿50例(29.41%);AL患儿各年龄组患病比例:0~4岁组57.65%、5~9岁组30.00%、10~15岁组12.35%;ALL患儿巨细胞病毒(CMV)、风疹病毒(RV)、弓形虫(TOX)、单纯疱疹病毒(HSV)、EB病毒的感染率分别为:2.50%、3.33%、1.67%、18.33%、6.67%;ALL患儿CMV、RV、TOX、HSV的感染率分别为:12.00%、8.00%、10.00%、32.00%、4.00%;AL患儿TORCH和EB病毒感染率均高于正常儿童对照组(x^2值分别为4.111、42.69、7.202、20.884、1.035,均P<0.05)。患儿同时存在一种或以上病原体感染、白血病患儿是否感染病原体与外周血白细胞计数高低无差异(均P>0.05)。结论儿童白血病的预防要从母体怀孕前做起。
Objective To understand the infection with TORCH and EB virus in children with acute leukemia （AL）. Methods Totally 120 newly-onset cases diagnosed with acute lymphocytic leukemia （ALL） confirmed by bone marrow cell morphology test were selected, and 50 cases of acute myeloid leukemia （AML） were recruited in the study. Serum specific immunoglobulin M （IgM） antibody was detected with ELISA for EB virus and TORCH （ cytomegalo virus （ CMV ）, herpes simplex virus （ HSV ）, rubella virus （ RV ） and toxoplasma （TOXO） ） , and WBC of peripheral blood was tested for analysis in terms of AL type and age with normal control groups. Results There were 120 cases of ALL （70.59%） and 50 cases of AML （29.41%）. Among cases of AL, 57.65% were children aged 0 - 4 years, 30.00% were children aged 5 -9 years and 12.35% were children aged 10 - 15 years. The infection rate of CMV, RV, TOXO, HSV and EBV among ALL cases was 2.50% , 3.33% , 1.67% , 18.33% and 6.67%, respectively, while it was 12.00% , 8.00% , 10.00%, 32.00% and 4.00% among AML cases, respectively. Children were infected with one or more virus. Whether children with AL was infected was not correlated with peripheral WBC （ both P 〉 0.05 ）. The infection rates of TORCH and EB among AL cases were higher than those among normal controls （X2 value was 4.111, 42.69, 7. 202, 20. 884 and 1. 035, respectively, all P 〈 0.05 ）, and the proportion of cases infected with TORCH and EB was different. Conclusion The preventive measures for AL should be taken before pregnancy.
出处
《中国妇幼健康研究》
2015年第6期1207-1210,共4页
Chinese Journal of Woman and Child Health Research
关键词
儿童
急性白血病
TORCH
EB病毒
感染
children
acute leukemia （AL）
TORCH
Epstein-Barr virus （EBV）
infection
