摘要
目的了解本院肿瘤患者感染铜绿假单胞菌的耐药情况，为临床治疗提供依据。方法收集本院2010-2013年临床分离的铜绿假单胞菌，采用K—B纸片扩散法进行药敏试验，并用WHONET5．6进行耐药性统计分析。结果4年间分离出铜绿假单胞菌株数不断上升，痰标本分离率最高为57．70％，其次是分泌物、脓液分别为18．13％、9．37％；科室主要分布在肿瘤内科占28．70％，放疗科占17．52％。药敏结果显示多粘菌素B敏感性最高，其次是亚胺培南、美罗培南、哌拉西林／他唑巴坦比较敏感，耐药率〈20％，头孢他啶、头孢吡肟、阿米卡星、环丙沙星、左氧氟沙星耐药率在20％～40％之间，呈逐年上升趋势，庆大霉素和氨曲南耐药比较严重，2013达到54．4％和43．6％。结论肿瘤患者免疫力低易并发医院感染，应合理使用抗菌药物，同时加强医护人员的感染意识和管理，避免交叉感染。
Objective To understand the situation of Pseudomonas aeruginosa（PAE） infection in tumor pa tients resistance in our hospital,and provide the basis for clinical therapy. Methods Pseudomonas aeruginosa（PAE） isolates collected in our hospital during 2010-2013, K-B method was used as drug sensitive test, and using whonetS. 6 to analyze the drug resistance. Results 4 years of isolated Pseudomonas aeruginosa（PAE） strains in the rise, from sputum specimens the highest rate of 57.70% ,followed by secretion, pus were 18.13 %, 9.37% ;department mainly accounted in department of tumor medicine for 28.70%,department of radiotherapy for 17.52%;Susceptibility results show that the polymyxin B sensitivity is highest, followed by the imipenem,meropenem, piperacillin / tazobactam is more sensitive, resistance rate 〈20%, ceftazidime, cefepime, amikacin, ciprofloxacin and levofloxacin resistance rates between 20-40%,rising trend year by year, gentamicin and aztreonam resistance is more serious in 2013 reached 54.4% and 43.6%. Conclusion Cancer patients with low immunity and complicated with nosocomial infection, should use antimicrohial agents rationally, and strengthening the awareness of infection and management staff, to avoid cross infection.
出处
《检验医学与临床》
CAS
2015年第A01期190-192,共3页
Laboratory Medicine and Clinic
关键词
肿瘤患者
铜绿假单菌
耐药性
tumor patients
Pseudomonas aeruginosa（PAE）
resistance
