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美多芭对帕金森病患者血小板中五羟色胺含量的影响与抑郁症状 被引量：13

To study the influence of madopar for serotonin in platelet and depressive symptoms of Parkinson's disease patients
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摘要 目的分析口服美多芭治疗帕金森病运动障碍时对体内五羟色胺(5-HT)含量变化与抑郁症状产生的影响。方法观察本院就诊的帕金森病患者35例口服美多芭1年后患者血小板5-HT含量的变化,同时给患者汉密尔顿抑郁量表(HAMD)评分,观察治疗前后患者精神症状改变。结果美多芭治疗1年后患者血小板中5-HT含量明显降低,HAMD评分结果较治疗前明显增高。结论美多芭治疗PD运动障碍症状的同时能导致体内的5-HT含量降低,这可能会加重患者的抑郁症状。 Objective To study the influence of madopar for 5-HT in platelet and depressive symptoms of Parkinson＇s disease patients. Methods We observed 5-HT in platelet of 35 PD cases in our hospital who take madopar at least one year. At the same time, we observed the mental symptoms change of every ease before and after the treatment. Results Madopar can significantly lower the 5-HT of platelet after one year, and HAMD score results show that madopar is significantly higher before treatment. Conclusion Madopar can damage serotonin neurons in the brain, which may enhance the patients with depressive symptoms.
作者 王永春 王钊 王伟
机构地区 邯郸市中医院 首都医科大学宣武医院
出处 《脑与神经疾病杂志》 2016年第2期85-87,共3页 Journal of Brain and Nervous Diseases
基金 邯郸市科学技术研究与发展计划项目(1323108090-6)
关键词 帕金森病 美多芭 五羟色胺 血小板 高效液相色谱分析 Parkinson＇s disease Madopar Serotonin Platelet High performance liquid chromatography
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献10

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二级参考文献27

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脑与神经疾病杂志
2016年 第2期

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