摘要
目的:探讨脑肿瘤切除术患者血清髓鞘碱性蛋白(MBP)的改变。方法:检测20例脑膜瘤(脑膜瘤组)、23例胶质瘤(胶质瘤组)、18例听神经瘤(听神经瘤组)患者术前及术后第1、3、7天血清MBP水平,另选择健康成年体检者21例(健康对照组)并检测其MBP水平,进行统计分析。结果:3个疾病组术后第1天、第3天血清MBP水平均升高,术后第7天降至或接近术前水平。脑膜瘤组和胶质瘤组不同病灶部位之间血清MBP水平差异无统计学意义(F=0.842,P=1.515;F=0.516,P=0.247)。各疾病组的血清MBP与术前、出院时卡氏功能状态评分(KPS)都不同程度地呈负相关(P<0.05)。胶质瘤组的血清MBP与肿瘤体积、瘤周水肿体积、手术时长等临床指标呈正相关(P<0.05)。结论:术后血清MBP先升高后降低的改变,反映术后脑损伤的进展、愈合的过程。术前血清MBP不能反映脑肿瘤类型,手术前后血清MBP的改变幅度与肿瘤类型、病灶部位无关。
Objective： To investigate the changes in serum level of myelin basic protein （MBP） in patients after intracranial tumor resection. Methods： Twenty patieints with meningioma （meningioma group）, 23 cases with glioma （glioma group） and 18 cases with intracranial acoustic neuroma （acoustic neuroma group）, as well as 21 healthy controls （control group） were enrolled. All participients have received a cerebral tumor excision at the hospital. The serum MBP levels in the tumor groups before operation and at postoperative days 1,3 and 7,and in the control group were examined and analyzed. Results： The serum MBP levels were increased on the 1st and 3rd postoperative days, then declined on postoperative day 7 in the 3 tumor groups. There was no significant differences in serum MBP levels between the different lesions in the groups meningioma and glioma （F=0.842 ,P=1.515 ;F= 0.516 ,P=0.247）. Only in the glioma group, there was a correlation between the serum MBP and volume of tumors, volume of edema, and duration of operation respectively. Conclusion： The changes in seral MBP levels may reflect the pathological progression in patients who underwent intracranial tumor resection.
出处
《神经损伤与功能重建》
2016年第1期42-45,共4页
Neural Injury and Functional Reconstruction
基金
广西壮族自治区教育厅高校科研项目(No.桂教YB2014078)
关键词
髓鞘碱性蛋白
颅内肿瘤
开颅手术
脑损伤
myelin basic protein
intracranial tumor
craniotomy
brain damage
