摘要
近来研究发现,长非编码RNA尿路上皮癌胚抗原1(UCA1)在多种肿瘤组织(膀胱癌、胃癌、肝癌、卵巢癌等)中呈高表达,表现为原癌基因的功能,在肿瘤的发生、发展中起着关键性作用。UCA1作为一种新的生物标记,在肿瘤的诊断、治疗以及预后中具有重要作用。本文结合国内外最新报道对UCA1在肿瘤研究中的进展作一综述。
Recently, high expression of long non-coding RNA urothelial carcinoma antigen 1 （ UCA1 ） has been found in vari- ous human carcinomas（ bladder urothelial carcinoma, gastric cancer, hepatocellular carcinoma, ovarian cancer, etc）acting as proto-on- cogene. UCA1 is playing an important role in the development and progression of tumors. As a novel biological marker, it is indispensi- ble during the process of diagnosis, therapy and prognosis. In this view, we summarize the latest progress, both domestic and overseas, on the advance of UCA1 in tumor research.
出处
《临床肿瘤学杂志》
CAS
2016年第1期88-92,共5页
Chinese Clinical Oncology
基金
国家自然科学基金资助项目(81472198)
江苏省科技厅临床医学科技专项资助项目(BL2014096)
江苏省医学重点人才基金资助项目(RC2011080)
