摘要
目的：探讨药物联合结膜瓣遮盖术治疗曲霉菌性角膜溃疡的效果.方法：回顾性分析2014-06/2015-06安徽省第二人民医院收治的15例（15只眼）真菌性角膜溃疡患者,通过病原学检查及显微形态学检查确诊为曲霉菌性角膜溃疡,经过5-7 d的抗真菌药物治疗后,无明显好转或加重,行结膜瓣遮盖术,观察术后视力、手术前、后眼部刺激症状及溃疡局部体征的变化情况.结果：平均随访6个月,相对于术前视力,术后视力提高6例（40%）,不变8例（53%）,下降1例（7%）,疼痛等主观症状减轻,溃疡瘢痕化12例（80%）,症状和体征无显著改善2例（13%）,症状和体征加重1例（7%）.结论：抗真菌药物联合结膜瓣遮盖术治疗曲霉菌性角膜溃疡是一种简易、安全、有效的治疗方案,尤其适合基层医院,能有效降低曲霉菌性角膜溃疡的致盲率,值得推广.
AIM： To investigate the effect of drugs combined conjunctival flap covering surgery in the treatment of aspergillus corneal ulcer. METHODS： A total of 15 cases with fungal corneal ulcer were retrospectively analysed and finally diagnosed as aspergillus corneal ulcer through etiological and morphological examination.After using antifungal drugs for 5 to 7 days,all cases did not get better or worse,then conjunctival flap covering surgery were performed. The postoperative visual acuity,ocular irritation symptom before and after sugery and local symptoms of ulcer were observed. RESULTS： All cases were followed up for 6 months.Compared with preoperative visual acuity,visual acuity improved in 6 eyes（40%）,remained unchanged in 8 cases（53%） and decreased in 1 cases（7%）. Subjective symptoms such as pain and so on relieved. Ulcer were scarring in 12 cases（80%）,improved in 2 cases（13%） and increased in 1 case（7%）. CONCLUSION： Drugs combined conjunctival flap covering surgery is a kind of simple,safe and effective treatment,which can can effectively reduce the incidence of blindness caused by aspergillus corneal ulcer,especially for primary hospital. It＇s worthy of promotion.
出处
《转化医学电子杂志》
2016年第1期26-28,共3页
E-Journal of Translational Medicine
关键词
角膜溃疡
曲霉菌
抗真菌药物
结膜瓣遮盖术
corneal ulcer
aspergillus
antifungal drugs
conjunctival flap covering surgery
