摘要
背景:人工关节从开始设计到临床应用已经经历了近一个世纪的历史,人工关节的先导为人工髋关节,随着在临床上的技术应用不断娴熟,推动了腕关节、肩关节、膝关节等人工关节的设计、应用及改进。目的:总结运动性关节损伤中人工关节材料的应用进展及性能特征。方法:由第一作者检索1980至2015年Pub Med数据库(http://www.ncbi.nlm.nih.gov/PubM ed)、万方数据库(http://wanfangdata.com.cn/)及CNKI中国期刊全文数据库(http://www.cnki.net/),以"sports;cartilage injury;Artificial Joint"为英文检索词,"运动,关节软骨损伤,人工关节"为中文检索词,对目前国内外人工关节的研究资料进行了分析和归纳,逐一介绍并分析了国内外常用的人工关节材料,并从材料科学的角度分析了各种材料在应用时的优劣,对目前常用人工关节的表面处理方法作了阐述,并从发展的角度指出了人工关节的研究方向。结果与结论:钛合金的表面改性可获得结合性能良好的表面陶瓷层,可有效提高钛合金的耐磨损性能。超高分子量聚乙烯的填充改性,可获得耐磨损性能良好的关节复合材料,有效减少超高分子量聚乙烯磨损颗粒的产生并降低其磨损颗粒引起的生物学反应。陶瓷人工关节的进一步研究与完善将是未来人工关节的发展方向。
BACKGROUND： The artificial joint has gone through nearly a century of history from the beginning of design to the clinical application. The forerunner of artificial joints is artificial hip joint. With the skilled technological application in clinic, the design, application and improvement of wrist, shoulder, knee and other artificial joints have been promoted. OBJECTIVE： To summarize the application progress and performance characteristics of artificial joint materials in exercise-induced articular cartilage injury. METHODS： Pub Med（http：//www.ncbi.nlm.nih.gov/Pub Med）, Wanfang database（http：//wanfangdata.com.cn/） and China National Knowledge Infrastructure（http：//www.cnki.net/） during 1980 to 2015 were retrieved by the first author. ＂Sports; Cartilage Injury; Artificial Joint＂ were taken as the key words in English and Chinese, respectively. Retrieved data were analyzed and summarized. The artificial joint materials commonly used at home and abroad were introduced and analyzed one by one. The clinical advantages and disadvantages of various materials were analyzed from the view of materials science. The surface treatment methods commonly used for artificial joints were described. The direction of the artificial joint research was pointed out from a development perspective. RESULTS AND CONCLUSION： The surface modification of titanium alloys can obtain surface ceramic layer with good performance, and can effectively improve the anti-wear properties of titanium alloys. The filling and modification of ultra-high molecular weight polyethylene can obtain joint composites with good anti-wear properties that can effectively reduce the production of ultra-high molecular weight polyethylene wear particles and the biological response induced by ultra-high molecular weight polyethylene wear particles. Further research and improvement of ceramic artificial joints will be the future direction of development of artificial joints.
出处
《中国组织工程研究》
CAS
北大核心
2015年第52期8492-8497,共6页
Chinese Journal of Tissue Engineering Research
基金
沈阳药科大学中青年教师事业发展支持计划资助课题(沈药大组人字[2014]9号文件)~~
