摘要
微小RNA（micro RNA,miRNA）是非编码的内源性小分子RNA,长度为21~25个核苷酸。微小RNA可与目标m RNA的3’-非翻译区进行互补结合,使得m RNA被降解而表达受到抑制,从而使得相应调控基因沉默。miRNA在诸多生理和病理过程中发挥重要作用。近年来,研究发现miRNA与肿瘤细胞增殖和凋亡相关,其多在肿瘤组织中异常表达,参与肿瘤的发生发展。主要分为＂原癌性miRNA＂和＂抑癌性miRNA＂。除表达水平外,miRNA碱基序列所发生的改变也可导致肿瘤的发生。本文主要就miRNA在原发性肝癌中的研究现状做相关综述,以期为未来进一步研究miRNA在肝癌中的作用和应用提供有益线索。
Micro RNAs（miRNAs） are a group of endogenous small noncoding RNAs, approximately 21~25 nucleotides in length. In mammals, their function is mainly repressing the m RNA transcripts via imperfect complementary sequences in the 3＇-UTR of target m RNAs. miRNAs play important roles in many physiological and pathological processes. Over the past decades, overwhelming studies have reported that miRNAs are associated with the proliferation and apoptosis of tumor cells. miRNAs aberrantly expressed in tumor tissues have significant roles in tumor induction, progression and recurrence. Depending on miRNA function and status in cancer, miRNAs are generally classified as tumor suppressor or onco-miRNAs. In addition to the deregulated expression levels and potentially mutations that altering a miRNA seed sequence could ablate target repression by tumor-suppressive miRNAs or allow for altered target selection, which could contribute to oncogenesis. In this review, an overview on the miRNAs study in primary liver cancer were given so as to provide useful clues to understand the significance of miRNAs in the future.
出处
《中国肝脏病杂志（电子版）》
CAS
2015年第4期8-10,共3页
Chinese Journal of Liver Diseases：Electronic Version
基金
辽宁省科学技术计划项目(2012225014)
