摘要
1例63岁男性高血压病患者口服苯磺酸氨氯地平5mg、1次／d，因血压波动加用替米沙坦80mg、1次／d。，2个月后患者丙氨酸转氨酶（ALT）543U／L，天冬氨酸转氨酶（AST）311U／L。停用苯磺酸氨氯地平及替米沙坦，改用福辛普利10mg、1次／d。8周后复查，ALT19U／L，AST25U／L，γ-谷氨酰转移酶34U／L，碱性磷酸酶68U／L，总胆红素14．8μmol／L，直接胆红素2．6μmol／L。因血压升高加用苯磺酸氨氯地平5mg、1次／d。加药后3个半月复查，ALT13U／L，AST28U／L，31．谷氨酰转移酶18U／L，碱性磷酸酶61U／L，总胆红素10．6μmoL／L，直接胆红素2．4μmol／L。
A 63-year-old male patient with hypertension received oral amlodipine besylate 5 mg once daily, telmisartan 80 mg once daily was added to his regimen because of the blood pressure variability. Two months later, his alanine aminotransferase （ALT） was 543 U/L and aspartate aminotransferase （AST） was 311 U/L. Amlodipine hesylate and telmisartan were stopped and switched to fosinopril 10 mg once daily. After eight weeks, laboratory tests revealed the following levels： ALT 19 U/L, AST 25 U/L, 7- glutamine transferase 34 U/L, alkaline phosphatase 68 U/L, total bilirubin 14.8 ~mol/1, and direct biliru- bin 2.6 μmol/L. Amlodipine hesylate 5 mg once daily was readministrated due to elevated blood pressure. After 3 and a half months, his liver function reexamination showed the following levels： ALT 13 U/L, AST 28 U/L, γ-glutamine transaminase 18 U/L, alkaline phosphatase 61 U/L, total bilirsbin 10. 6μmol/l, direct biliruhin 2.4μmoL/L.
出处
《药物不良反应杂志》
CSCD
2015年第6期461-462,共2页
Adverse Drug Reactions Journal
关键词
替米沙坦
药物性肝损伤
Telmisartan
Drug-induced liver injury
