摘要
目的探讨影响双相障碍复发的病因及其相关因素，为早期治疗双相障碍和预防复发提供依据。方法采用病例对照的研究方法，将确诊的96例双相障碍患者依据是否发生复发分为病例组和对照组，对两组患者进行跟踪随访，收集可能影响复发的相关因素，采用单因素和多因素分析方法来筛选影响双相障碍复发的相关因素。结果双相障碍2年内复发率为51．0％（49／96）；多因素分析结果显示应用心境稳定剂（OR=0．157）、应用抗精神病药（OR=0．258）、长期使用稳定剂（OR=0．207）为双相障碍复发的保护因素，而长期使用苯二氮卓类（OR=3．931）、睡眠障碍（OR=7．001）、延误首次治疗（OR=3．607）则为复发的危险因素。结论双相障碍具有很高的复发率，双相障碍复发与药物治疗的合理性和充分性、物质滥用、睡眠障碍、延误首次治疗、躯体性疾病、生活事件等因素密切相关。
Objective To explore the causes and correlated factors of the relapse of bipolar disorder, and to provide ba- sis for early treating of bipolar disorder and preventing of relapse. Methods With case-control study method, 96 confirmed ca- ses with bipolar disorder were divided into case group and control group according to relapse, and we collected possible correlated factors of the relapse of bipolar disorder through following-up. Then, single factor and multiple factors analysis methods were used to screen influencing factors of bipolar disorder. Results The incidence rate of relapse of bipolar disorder in 2 years was 51.0% （49/96）. Multiple factors analysis result showed that the protective factors of the relapse of bipolar disorder included use of mood stabilizer （OR=0. 157）, use of antipsychotics （OR=0. 258） and long-term use of stabilizer （OR=0. 207）, while the risk fac- tors of the relapse of bipolar disorder contained long-term use of benzodiazepine （ OR = 3. 931 ）, somnipathy （ OR = 7. 001 ） and delayed first treatment （ OR = 3. 607）. Conclusion There is a high relapse rate of bipolar disorder, and it is intimately correla- ted with rationality and sufficiency of medication, substance abuse, somnipathy, delayed first treatment, somatic disease and life events.
出处
《中国医院统计》
2015年第6期436-438,共3页
Chinese Journal of Hospital Statistics
关键词
双相障碍
复发
病因
影响因素
危险因素
Bipolar disorder Relapse Etiological factor Influencing factors Risk factors
