摘要
目的:研究美洲大蠊的化学成分。方法:采用色谱手段,结合波谱方法分离鉴定美洲大蠊的化学成分。结果:从美洲大蠊乙醇提取物的乙酸乙酯萃取部位中分离得到10个环肽成分,分别鉴定为:8-羟基-3,4-二氢喹啉-2(1H)-酮(1)、cyclo-(L-Phe-L-Pro)(2)、cyclo-(Pro-Ile)(3)、cyclo-(L-Pro-D-Leu)(4)、brevianamide F(5)、cyclo-(IleAla)(6)、cyclo-(L-Val-L-Pro)(7)、cyclo-(L-Pro-L-Tyr)(8)、环-(色氨酸-缬氨酸)-二肽(9)、(-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(10)。结论:其中,化合物2~9为首次从美洲大蠊中分离得到。
Objective: To study the chemical constituents in Periplaneta americana. Methods: The chemical constituents were separated and purified by chromatographic methods after solvent extraction and identified by spectroscopic analyses. Results: Ten compounds were isolated from Periplaneta americana and identified as following: 8-hydroxy-3,4-dihydroquinolin-2(1H)-one(1),cyclo-( L-Phe-LPro)(2),cyclo-( Pro-Ile)(3),cyclo-( L-Pro-D-Leu)(4),brevianamide F(5),cyclo-( Ile-Ala)(6),cyclo-( L-Val-L-Pro)(7),cyclo-( L-Pro-L-Tyr)(8),cyclo-( Trp-Val)-dipeptide(9),and(-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(10). Conclusion: Compounds 2~9 are isolated from Periplaneta americana for the first time.
出处
《中药材》
CAS
CSCD
北大核心
2015年第10期2038-2041,共4页
Journal of Chinese Medicinal Materials
基金
江西省自然科学基金(20142BAB215067
2008GQY0109)
江西中医药大学校基金(JZYC15S34)
关键词
美洲大蠊
环肽
Periplaneta americana(Linnaeus)
Cyclic peptide