摘要
目的探讨羊水非多态性染色体核型分析在细胞遗传学产前诊断中的应用及意义。方法通过对各种具备产前诊断指征的1887例妊娠妇女,在知情选择的情况下行羊膜腔穿刺术及羊水细胞遗传学检查。结果本实验室1887例羊水中共检测出77例非多态性异常,异常率为4.08%(77/1887),其中染色体数目异常53例,染色体结构异常10例,嵌合体14例。结论孕中期羊水细胞染色体核型非多态性分析具有十分重要的意义。
Objective： To investigate the application and significance of non-polymorphic chromosome karyotype analysis in the cytogenetic prenatal diagnosis. Methods： 1887 cases of pregnant women with the right kinds of prenatal diagnosis indications, in the case of informed choice, amniocentesis surgery and amniotic fluid cytogenetic analysis. Results： 1887 cases out of 77 cases were detected in the non-polymorphic abnormalities, abnormal rate of 4.08% （77/1887） , where 53 cases of the number of chromosomal abnormalities, 10 cases of chromosome structural abnormalities, 14 cases of chimeric. Conclusion： nonpolymorohic chromosome karvotvoe analysis is very imoortant.
出处
《中国优生与遗传杂志》
2016年第2期53-54,57,共3页
Chinese Journal of Birth Health & Heredity
关键词
非多态性
羊水
染色体核型分析
Non-polymorphic
Amniotic fluid
Chromosome karyotype analysis
