摘要
揭示发病机制是心律失常诊断、治疗、药物研发和设备设计的关键.整合当前在心脏分子生物学、生物化学、生理学及解剖学方面的最新成果,构建从离子通道、心肌细胞、心肌纤维、心肌组织、心脏器官到躯体各个层次的多尺度多模态心脏电生理模型,用于系统研究微观局部变化发生、发展、转化为宏观心律失常表现的过程,将彻底改变传统从基因突变、蛋白质表达、细胞电生理、临床表现单独研究心律失常的方式,实现微观与宏观研究的统一,使心脏电生理模型成为系统研究心律失常发病机制的有力手段.本文综述了心脏电生理模型的构建方法和研究进展,讨论了多尺度心脏电生理模型在揭示心律失常机制研究中的作用和地位,给出了基于心脏电生理模型心律失常研究的挑战和重要发展方向.
Revealing the pathogenesis of arrhythmia is a key task involved in diagnosis, treatment, drug development and equipment design. Multi-scale and multi-mode models of cardiac electrophysiology from ion channel, cell, fiber, tissue, heart to torso-heart integrated various physiological and pathological data from molecular biology, biochemistry, physiology and anatomy of the heart, changed research methods based on gene mutation, protein expression, cell electrophysiology and clinical symptoms completely and created a systematic approach for studying development and transformation of arrhythmias from microscopic changes to macroscopic pathology. The most important is that the cardiac electrophysiological model, which is a powerful tool for studying the mechanisms of arrhythmia, becomes the unified method of micro and macro research. In this paper, we summarized the method of constructing cardiac electrophysiological models, discussed the role and status of the multi-scale cardiac electrophysiological model in the study of cardiac arrhythmia mechanism, and outlined important research prospects and challenges of the electrophysiological modeling and simulation of arrhythmia in the future.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2016年第2期128-140,共13页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(61173086
61571165)资助项目~~
关键词
系统生物学
生理组学
计算心脏学
虚拟心脏
心律失常
心脏电生理模型
建模与仿真
systems biology
physiology
computational cardiology
virtual heart
cardiac arrhythmia
cardiac electrophysiology model
modeling and simulation
