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普拉克索联合高压氧舱治疗帕金森病合并睡眠障碍的疗效观察 被引量：27

Curative effect of pramipexole in combination with hyperbaric oxygen therapy in Parkinson's disease patients with dyssomnia
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摘要 目的探讨普拉克索联合高压氧舱治疗帕金森病(Parkinsons disease,PD)合并睡眠障碍的疗效。方法选取符合修订Hoehn-Yahr(H-Y)分级≤3级且合并睡眠障碍的PD患者60例,根据治疗随机分为3组,20例普拉克索组;20例高压氧舱组;20例普拉克索联合高压氧舱治疗(联合)组,疗程均为2个月,记录患者治疗前后行全夜多导睡眠图监测参数、匹兹堡睡眠质量指数量表(PQSI)及爱泼沃斯思睡量表(ESS)、统一PD评定量表运动检查(UPDRS-Ⅲ)及H-Y分级评分。结果与普拉克索组和高压氧舱组比较,联合组治疗后PQSI[(4.35±1.21)分vs(6.87±1.82)分和(6.53±1.67)分]、ESS降低[(2.18±3.51)分vs(5.62±4.32)分和(5.15±3.95)分],卧床时间[(501.24±76.92)min vs(421.38±69.82)min和(410.25±58.47)min]、总睡眠时间升高[(259.12±138.33)min vs(213.21±152.24)min和(215.39±149.55)min],3组睡眠效率、睡眠中觉醒次数比较,差异有统计学意义(P<0.05);3组UPDRS-Ⅲ评分、H-Y分级比较,差异无统计学意义(P>0.05)。结论普拉克索联合高压氧舱治疗PD合并睡眠障碍患者时,在提高睡眠效率、合理改善睡眠结构等方面有更好的优势。 Objective To study the curative effect of pramipexole in combination with hyperbaric oxygen therapy in PD patients with dyssomnia.Methods Sixty PD patients with dyssomnia with their Hoehn-Yahr（H-Y）stage≤Ⅲ were divided into pramipexole treatment group（n=20）,hyperbaric oxygen treatment group（n=20）,combined pramipexole and hyperbaric oxygen treatment group（combined treatment group,n=20）and treated for 2months.Their whole night PSG monitoring parameters,Pittsburgh sleep quality index（PQSI）,Love Splashing Voss Drowsiness Scale（ESS）score and unified PD rating scale movement examination（UPDRS-Ⅲ）score,and H-Y stage were recorded before and after treatment.Results The PQSI and ESS score were significantly lower whereas the bed time was significantly longer in combined treatment group than in pramipexole treatment group and hyperbaric oxygen treatment group after treatment（4.35±1.21 vs 6.87±1.82 and 6.53±1.67,2.18±3.51 vs 5.62±4.32 and 5.15±3.95,501.24±76.92 min vs 421.38±69.82 min and 410.25±58.47 min,P〈0.05）.The total sleep time,sleep efficiency,awaking frequency in sleep were different（259.12±138.33 min,57.48%±26.35%,12.85±12.17,P〈0.05）.However,no signifi-cant difference was found in UPDRS-Ⅲ score,H-Y stage,sleep latent period（P〉0.05）.Conclusion Pramipexole in combination with hyperbaric oxygen therapy can improve the sleep efficiency and sleep structure in PD patients with dyssomnia.
作者 潘燕 罗梅 王新源
机构地区 新疆医科大学第五附属医院神经内科 新疆医科大学第五附属医院心内科 新疆乌鲁木齐市睡眠研究治疗中心
出处 《中华老年心脑血管病杂志》 CAS 2016年第2期125-128,共4页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词 帕金森病 高压氧 睡眠障碍 多道睡眠描记术 睡眠 快速眼运动 普拉克索 Parkinson disease hyperbaric oxygenation sleep disorders polysomnography sleep REM pramipexole
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献17

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共引文献62

同被引文献271

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引证文献27

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中华老年心脑血管病杂志
2016年 第2期

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