摘要
目的分析依达拉奉治疗血管性帕金森综合征的临床疗效。方法选取78例血管性帕金森综合征患者为研究对象，按照随机数字表法将患者分为治疗组和对照组，每组39例，对照组给予阿司匹林、克瑞帕和美多巴进行常规治疗，治疗组在常规治疗的基础上给予依达拉奉进行治疗，2个疗程后，比较分析两组患者的帕金森病综合评分量表（UPDRS）评分、不良反应发生情况以及临床疗效。结果治疗组总有效率为92．31％，显著高于对照组的66．66％，差异有统计学意义（X2=4．251，P〈0．05）；治疗后，两组患者的日常生活活动评分和运动功能评分均有所降低，但差异均无统计学意义（均P〉0．05）；观察组患者的精神、情绪和行为评分与对照组比较显著降低（t=4．568、4．113、4．345，均P〈0．05）；治疗组患者未见明显不良反应。结论依达拉奉治疗血管性帕金森综合征临床疗效显著，不良反应少，耐受性好，值得临床借鉴。
Objective To analyze the clinical treatment effect of edaravone on vascular Pm＇kinson syndrome. Methods 78 patients in our hospital who accepted treatment were selected as the study samples： They were divided into two groups which included treatment group （ n = 39） and control group （ n = 39 ） by random number table method. The control group were given routine treatment, mainly including madopar, aspilin and cripar, however, the treatment group administered edaravone on the basis of conventional treatment. After total 2 periods of treatment, the score of UPDR,therapeutic efficacy and adverse reactions were recorded and compared. Results The therapeutic effective rate was 92.31% in the treatment group ,which was significantly higer than that of the control group （66.66%）, and the difference was statistical significance （X2 = 4. 251 ,P 〈 0.05 ）. After treatment, scores and motor function in two groups of patients with activities of daily living score were decreased, but the difference was no statistical significance （ P 〉 0.05 ）. The patients in the observation group mental, e - motional and behavioral score were lower than those of the control group （ t = 4. 568,4.113,4. 345, all P 〈 0.05 ）, and there was no adverse reaction in the treatment group. Conclusion The treatment of edaravone in vascular Parkinson syndrome can obviously enhance the therapeutic effect,improve the treatment efficiency, has less adverse reaction and good tolerance,it is worth for clinical reference.
出处
《中国基层医药》
CAS
2016年第1期51-54,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
依达拉奉
血管性帕金森综合征
临床疗效
Edaravone
Vascular parkinson syndrome
Clinical treatment effect
