摘要
目的为了解血清Chemerin检测在急性脑梗死患者中的临床意义。方法清晨空腹采静脉血,采用酶联免疫吸附试验测定Chemerin水平;采用散射比浊法测定C反应蛋白;采用全自动生化分析仪检测血糖血脂。结果与对照组相比,急性脑梗死组患者的空腹血糖、甘油三酯及低密度脂蛋白胆固醇水平均较高,且两组相比差异具有统计学意义(P<0.05),Chemerin水平、C反应蛋白水平也显著升高,两组差别显著(P<0.01)。而急性脑梗死组患者的高密度脂蛋白胆固醇显著低于对照组(P<0.05)。急性脑梗死患者的Chemerin水平与体重指数、空腹血糖、甘油三酯、低密度脂蛋白胆固醇、C反应蛋白及NIHSS神经缺损评分呈正相关,而与年龄、高密度脂蛋白胆固醇水平无相关。结论急性脑梗死患者血浆Chemerin升高的程度与观察对象的神经功能缺损程度之间存在明显的相关性,也可以说是在某些方面反映了病变的现状通过监测Chemerin的水平,为评价急性脑梗死治疗的有效性及疾病防控方面带来充足的论据。随着临床研究及Chemerin的作用机制被逐渐认识,Chemerin极有可能会成为临床上心血管疾病防控的新靶点。
Objective To investigate the clinical significance of detection of serum Chemerin in patients with acute cerebral infarction. Methods Fasting collected venous blood,by enzyme linked immunosorbent assay for the determination of Chemerin level; by scattering turbidimetry for the determination of C- reactive protein; using full automatic biochemical analyzer was used to measure the levels of blood glucose and blood lipid. Results Compared with the control group,acute cerebral infarction patients with fasting blood glucose,triglyceride and low density lipoprotein cholesterol levels were higher in both groups,and the difference has statistical significance（ P 〈0. 05）,Chemerin levels,C- reactive protein levels were also significantly elevated,two groups of difference significant（ P 〈0. 01）. High density lipoprotein cholesterol in patients with acute cerebral infarction group was significantly lower than the control group（ P 〈0. 05）.Chemerin levels in patients with acute cerebral infarction with a body mass index,fasting blood glucose,triglyceride,low density fat cholesterol,C- reactive protein and NIHSS score defect positively related but nothing related with age,high density lipoprotein cholesterol levels. Conclusions Significant correlation exists between the degree of neurologic impairment of acute cerebral infarction of elevated plasma Chemerin level and observation of the object,it can be said is in some respects reflect the disease status through the monitoring of Chemerin level and for the evaluation of acute cerebral infarction treatment efficacy and disease control and prevention has adequate arguments. With the mechanism of clinical research and Chemerin is increasingly being recognized Chemerin is likely to will become a new target for clinical cardiovascular disease prevention and control.
出处
《航空航天医学杂志》
2016年第1期29-31,共3页
Journal of Aerospace medicine
