摘要
目的：观察依那普利叶酸片治疗H型高血压的疗效。方法将196例H型高血压合并颈动脉硬化的患者，按数字表法随机分为依那普利叶酸片组（依叶组99例）和依那普利组（依那组97例），分别口服依那普利叶酸片、依那普利片，每天1次。连续服用10个月，比较两组治疗前后血压控制水平，血浆同型半胱氨酸水平以及颈动脉内膜中层厚度。结果依叶组治疗前收缩压（159．51±8．55）mmHg，舒张压（98．11±7．44）mmHg，治疗后收缩压（138．68±7．82）mmHg，舒张压（82．98±5．22）mmHg；依那组治疗前收缩压（160．10±9．12）mmHg，舒张压（97．88±7．62）mmHg，治疗后收缩压（139．47±7．99）mmHg，舒张压（83．12±5．57）mmHg。两组治疗前后的血压值比较差异均有统计学意义（均 P ＜0．05），组间血压比较差异均无统计学意义（均 P ＞0．05）。依叶组治疗前血浆同型半胱氨酸浓度为（16．89±5．62）μmol／L，治疗后（10．37±3．06）μmol／L，治疗前后血浆同型半胱氨酸浓度比较差异均有统计学意义（P ＜0．05）；依那组治疗前（17．11±6．33）μmol／L，治疗后（16．88±6．48）μmol／L，治疗前后血浆同型半胱氨酸浓度比较差异均无统计学意义（P ＞0．05）。依叶组颈动脉内膜中层厚度治疗前（1．28±0．33）mm，治疗后（1．08±0．36）mm，治疗前后比较差异均有统计学意义（P ＜0．05），依那组治疗前（1．29±0．38）mm，治疗后（1．31±0．43）mm，治疗前后比较差异均无统计学意义（P ＞0．05）。结论依那普利叶酸片治疗 H 型高血压疗效显著，血压和血浆同型半胱氨酸水平同时降低，并可延缓动脉粥样硬化的进度。
Objective To observe the efficacy of enalapril folic acid in the treatment of H type hypertension. Methods 196 H type hypertension patients with carotid atherosclerosis were randomly divided into the enalapril folic acid tablets group（leaf group 99 cases）and the control group（enalapril group 97 cases）,respectively,enalapril folic acid tablets and enalapril,once a day.Continuous administration of 10 months,before and after treatment,the blood pressure control level,plasma homocysteine levels and carotid intima media thickness were compared between the two groups.Results ,Before and after treatment,the systolic blood pressure in the leaf group were （159.51 ±8.55）mmHg, （138.68 ±7.82）mmHg,and the diastolic blood pressure were （98.11 ±7.44）mmHg,（82.98 ±5.22）mmHg.In the enalapril group,before and after treatment,the systolic blood pressure were （160.10 ±9.12）mmHg,（139.47 ± 7.99）mmHg,and the diastolic blood pressure were （97.88 ±7.62）mmHg,（83.12 ±5.57）mmHg.Blood pressure before and after treatment in the two groups were significantly different（all P 〈0.05）,there were no significant differ-ence between the two groups（all P 〉0.05）.In the leaf group,before and after treatment,the plasma homocysteine concentrations were （16.89 ±5.62）μmol/L,（10.37 ±3.06）μmol/L,there was significant difference（P 〈0.05）, and in the enalapril group before and after treatment,the plasma homocysteine concentrations were （17.11 ± 6.33）μmol/L,（16.88 ±6.48）μmol/L,there was no significant difference（P 〉0.05）.In the leaf group,before and after treatment the carotid artery intima media thickness were （1.28 ±0.33）mm,（1.08 ±0.36）mm,there was sig-nificant difference（P 〈0.05）,and in the enalapril group before and after treatment the carotid artery intima media thickness were （1.29 ±0.38）mm,（1.31 ±0.43）mm,there was no significant difference（P 〉0.05）.Conclusion Enalapril folic acid tablets in treatment of H type hypertension has significant efficacy,it can reduce blood pressure and plasma homocysteine levels and delay the progression of atherosclerosis.
出处
《中国基层医药》
CAS
2016年第2期282-285,共4页
Chinese Journal of Primary Medicine and Pharmacy
