摘要
目的:观察超敏C反应蛋白(hs-CRP)、降钙素原(PCT)和动脉血气分析在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压患者的血液中的变化,探讨其相关性及临床意义。方法:选取2014年1-12月广州市第一人民医院呼吸内科的AECOPD患者100例,分为对照组(单纯AECOPD组,50例)、肺动脉高压组(AECOPD合并肺动脉高压组,50例),行肺功能、心脏彩超检查(检测肺动脉压力),血液hs-CRP、PCT和动脉血气分析检查。结果:肺动脉高压组血液hs-CRP、PCT水平及动脉CO2分压水平均高于对照组(P<0.05);肺动脉高压组动脉血氧分压水平低于对照组(P<0.05)。肺动脉高压组患者1年内COPD急性加重次数≥2次的人数高于对照组(P<0.05)。血清hs-CRP、PCT水平与肺动脉收缩压呈正相关,动脉血氧分压与肺动脉收缩压呈负相关。结论:hs-CRP、PCT、血氧参与了COPD合并肺动脉高压的形成,全身炎症在COPD继发肺动脉高压的发病中发挥着重要作用。
Objective To observe the changes of serum hypersensitive C-reactive protein（hs-CRP）, serum procalcitonin（PCT） and arterial blood gas in AECOPD patients complicated with pulmonary hypertension（PH）.Methods 100 patients with AECOPD admitted（from January to December, 2014） in respiratory department of our hospital were enrolled in the research. 50 patients were classified as the control group（AECOPD without PH）and 50 patients as the PH group（AECOPD with PH）. Pulmonary function, pulmonary pressure（assessed by Doppler echocardiography）, hs-CRP, PCT and arterial blood gas were analyzed. Results The levels of hs-CRP,PCT and Pa CO2 in the PH group were significantly higher than those in the control group（P 〈0. 05）. The level of Pa O2 in the PH group was significantly lower than that in the control group（P 〈0. 05）. The number of patients in the PH group who had at least twice AECOPD within a year was significantly larger than that in the control group（P 〈0. 05）. Levels of hs-CRP and PCT had a positively linear relationship with PASP, while Pa O2 was negatively correlated with PASP. Conclusion Hs-CRP, PCT and blood gas are involved in the formation of AECOPD patients complicated with PH, suggesting that systemic inflammation plays a role in the pathogenesis of secondary PH in AECOPD.
出处
《实用医学杂志》
CAS
北大核心
2016年第2期196-199,共4页
The Journal of Practical Medicine
基金
国家自然科学基金(青年)项目(编号:81200037)
关键词
慢性阻塞性肺疾病
肺动脉高压
超敏C反应蛋白
降钙素原
血氧分压
Chronic obstructive disease
Pulmonary hypertension
Hypersensitive C-reactive protein
Procalcitonin
Partial pressure of blood oxygen
