摘要
全髋关节置换术后最常见的并发症是由无菌性松动引起的假体周围骨溶解。在该病理过程中,磨损颗粒被巨噬细胞吞噬并激活巨噬细胞和诱导其分化,最终导致骨吸收作用的发生。巨噬细胞被激活后会引起复杂的生物级联反应,激活骨溶解相关通路。近年来,生物诱导因子机制及调节方式开始逐渐被大家重视,通过磨损颗粒诱导骨溶解的发生可知各个通路及诱导因子的相互协调作用,了解这一机制可加速解决假体置换术后的松动问题。
The most frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active biological process initiated in response to wear debris. The eventual response to this process is the activation of macrophages and loss of bone. Activation of macrophages initiates a complex biological cascade resulting in the final common pathway of an increase in osteolytic activity. The biological initiators, mechanisms for and regulation of this process are beginning to be understood. Here explores current concepts in the causes of, and underlying biological mechanism resulting in periprosthetic osteolysis, so as to solve the problem of loosening of prosthesis replacement.
出处
《医学综述》
2016年第3期460-462,共3页
Medical Recapitulate
